ArticleJournal of human genetics2003
Prevalence of the mitochondrial DNA A1555G mutation in sensorineural deafness patients in island Southeast Asia.
Article in Journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 73 citations in OpenAlex.
- Prevalence of the mitochondrial 1555 A>G and 1494 C>T mutations in a community-dwelling population in Japan.Human genome variation · 2020Article
- Aminoglycoside-associated nonsyndromic deafness and speech disorder in mitochondrial A1555G mutation in a family: A case report.Medicine · 2018Article
- Analysis of mutation spectrum of common deafness-causing genes in Hakka newborns in southern China by semiconductor sequencing.Medicine · 2018Observational
- A study of deafness-related genetic mutations as a basis for strategies to prevent hereditary hearing loss in Hebei, China.Intractable & rare diseases research · 2015Article
- Mutations in the two ribosomal RNA genes in mitochondrial DNA among Finnish children with hearing impairment.BMC medical genetics · 2015Article
- Developing regional genetic counseling for southern Chinese with nonsyndromic hearing impairment: a unique mutational spectrum.Journal of translational medicine · 2014Article
- Genetic mutations in nonsyndromic deafness patients of Chinese minority and Han ethnicities in Yunnan, China.Journal of translational medicine · 2013Article
- Investigation of the A1555G mutation in mitochondrial DNA (MT-RNR1) in groups of Brazilian individuals with nonsyndromic deafness and normal-hearing.Indian journal of human genetics · 2013Article
- Frequency and spectrum of mitochondrial 12S rRNA variants in 440 Han Chinese hearing impaired pediatric subjects from two otology clinics.Journal of translational medicine · 2011Article
- Newborn genetic screening for hearing impairment: a preliminary study at a tertiary center.PloS one · 2011Article
- Mitochondrial 12S rRNA variants in 1642 Han Chinese pediatric subjects with aminoglycoside-induced and nonsyndromic hearing loss.Mitochondrion · 2010Article
- Modifiers of hearing impairment in humans and mice.Current genomics · 2010Article
- Comprehensive molecular etiology analysis of nonsyndromic hearing impairment from typical areas in China.Journal of translational medicine · 2009Article
- The genetic bases for non-syndromic hearing loss among Chinese.Journal of human genetics · 2009Review
- Mitochondrial oxidative damage and apoptosis in age-related hearing loss.Mechanisms of ageing and developmentReview
- Screening of the mitochondrial A1555G mutation in patients with sensorineural hearing loss.Brazilian journal of otorhinolaryngologyArticle
- Study of a Brazilian family presenting non-syndromic hearing loss with mitochondrial inheritance.Brazilian journal of otorhinolaryngologyArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A mtDNA A1555G base substitution in a highly conserved region of the 12S rRNA gene has been reported to be the main cause of aminoglycoside induced deafness. This mutation is found in approximately 3% of Japanese and 0.5-2.4% of European sensorineural deafness patients. We report a high prevalence (5.3%) of the A1555G mutation in sensorineural deafness patients in Sulawesi (Indonesia). Our result confirms the importance of determining the prevalence of the mtDNA A1555G mutation in different populations, and the need for mutation detection before the administration of aminoglycoside antibiotics.
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