ArticleEuropean journal of applied physiology2003
Downhill running in rats: influence on neutrophils, macrophages, and MyoD+ cells in skeletal muscle.
Article in European journal of applied physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Who cites it
29 citing papers in PubMed.
- Short-Wave Diathermy Pretreatment and Inflammatory Myokine Response After High-Intensity Eccentric Exercise.Journal of athletic training · 2015Trial
- Skeletal Muscle Damage and Inflammation.Advances in experimental medicine and biology · 2025Review
- ApoE deficiency protects from mRNA vaccine-induced mitochondrial dysfunction at the injection site under metabolic stress.Theranostics · 2025Article
- Article
- Regenerating Myofibers after an Acute Muscle Injury: What Do We Really Know about Them?International journal of molecular sciences · 2023Review
- Molecular feature of neutrophils in immune microenvironment of muscle atrophy.Journal of cellular and molecular medicine · 2022Review
- Mitochondrial Dysfunctions and Potential Molecular Markers in Sport Horses.International journal of molecular sciences · 2022Review
- Article
- Phytoecdysteroids Accelerate Recovery of Skeletal Muscle Function FollowingFrontiers in rehabilitation sciences · 2021Article
- Preconditioning contractions prevent the delayed onset of myofibrillar dysfunction after damaging eccentric contractions.The Journal of physiology · 2018Article
- Response of macrophages in rat skeletal muscle after eccentric exercise.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2018Article
- The Secretory Leukocyte Protease Inhibitor mRNA expression is involved with inflammatory control after downhill exercise in the triceps brachii intermediary head in Wistar rats.Journal of muscle research and cell motility · 2017Article
- Macrophage depletion by clodronate liposome attenuates muscle injury and inflammation following exhaustive exercise.Biochemistry and biophysics reports · 2016Article
- Inflammation during skeletal muscle regeneration and tissue remodeling: application to exercise-induced muscle damage management.Immunology and cell biology · 2016Review
- The effect of estrogen usage on eccentric exercise-induced damage in rat testes.Iranian Red Crescent medical journal · 2015Article
- Eccentric exercise 48 h prior to simulated diving has no effect on vascular bubble formation in rats.European journal of applied physiology · 2015Article
- Hepatoprotective effect of 17β-estradiol as antioxidant modulators against stress damage.Hepatitis monthly · 2015Article
- Downhill exercise-induced changes in gene expression related with macrophage polarization and myogenic cells in the triceps long head of rats.Inflammation · 2015Article
- GSK3β inhibition and LEF1 upregulation in skeletal muscle following a bout of downhill running.The journal of physiological sciences : JPS · 2014Article
- Regenerative responses in slow- and fast-twitch muscles following moderate contusion spinal cord injury and locomotor training.European journal of applied physiology · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The accumulation of neutrophils and macrophages, as well as the activation of satellite cells, are early events following skeletal muscle injury. We examined the temporal relationship between changes in neutrophils, macrophages, and MyoD protein, a marker of satellite cell activation, after injurious exercise. Male rats ( n=47) performed an intermittent downhill (-16% grade) running (17 m/min) protocol and the solei were obtained at 0, 2, 6, 24, 48, or 72 h post-exercise. Neutrophils, macrophages (ED1 and ED2), and MyoD+ cells were determined in muscle cross sections using immunohistochemistry. Downhill running increased ( P<or=0.05) the percentage of injured fibers and elevated blood creatine kinase activity. Neutrophils were elevated 18-fold relative to controls at 24 h post-exercise. ED1 macrophages were elevated four- and twofold at 24 and 48 h post-exercise, respectively. Neither ED2 macrophages nor MyoD+ cells were elevated post-exercise. These observations may indicate that elevations in neutrophils and ED1 macrophages after injurious exercise are not temporally associated with an increase in satellite cell activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.