ArticleImmunogenetics2003
Fugu rubripes possesses genes for the entire set of the ITAM-bearing transmembrane signal subunits.
Article in Immunogenetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Phylogenetic and structural insights into the origin of C-type lectin Mincle in vertebrates.Immunogenetics · 2025Article
- A survey of the adaptive immune genes of the polka-dot batfish Ogcocephalus cubifrons.BMC immunology · 2023Article
- On the relationship between extant innate immune receptors and the evolutionary origins of jawed vertebrate adaptive immunity.Immunogenetics · 2022Review
- Histocompatibility and Reproduction: Lessons from the Anglerfish.Life (Basel, Switzerland) · 2022Review
- Molecular characterization of the CD79a and CD79b and its role against Aeromonas hydrophila infection in Chinese sucker (Myxocyprinus asiaticus).Fish physiology and biochemistry · 2017Article
- Zebrafish B Cell Development without a Pre-B Cell Stage, Revealed by CD79 Fluorescence Reporter Transgenes.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Retention of duplicated ITAM-containing transmembrane signaling subunits in the tetraploid amphibian species Xenopus laevis.Developmental and comparative immunology · 2015Article
- B cell receptor accessory molecule CD79α: characterisation and expression analysis in a cartilaginous fish, the spiny dogfish (Squalus acanthias).Fish & shellfish immunology · 2013Article
- Expansion and diversification of the signaling capabilities of the CD2/SLAM family in Xenopodinae amphibians.Immunogenetics · 2011Article
- A molecule in teleost fish, related with human MHC-encoded G6F, has a cytoplasmic tail with ITAM and marks the surface of thrombocytes and in some fishes also of erythrocytes.Immunogenetics · 2010Article
- DAP10- and DAP12-associated receptors in innate immunity.Immunological reviews · 2009Review
- B cell receptor accessory molecules in the channel catfish, Ictalurus punctatus.Developmental and comparative immunology · 2008Article
- Article
- A novel family of diversified immunoregulatory receptors in teleosts is homologous to both mammalian Fc receptors and molecules encoded within the leukocyte receptor complex.Immunogenetics · 2006Article
- An evolutionarily mobile antigen receptor variable region gene: doubly rearranging NAR-TcR genes in sharks.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Characterization and expression analysis of CD3varepsilon and CD3gamma/delta in fugu, Takifugu rubripes.Immunogenetics · 2005Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transmembrane signaling subunits (TSSs) bearing the immunoreceptor tyrosine-based activation motif (ITAM) play a crucial role in triggering the effector functions of mammalian leukocytes. The involvement in key immune reactions and obvious extension through duplication events make TSSs valuable markers of the evolution of the immune system. We surveyed the genomic sequences of the teleostean fish Fugu rubripes for the presence of genes encoding these accessory molecules. Automatic gene prediction was not efficient because of the poor ability of the programs used to recognize the short exons encoding the intracellular regions of TSSs. However, the unique compactness of the Fugu genome and the conservation of the exon/intron arrangements of the TSS genes facilitated their recognition by visual inspection of the candidate genomic sequences. Evidence for the presence of the CD3epsilon, CD3gamma/delta, CD79a, CD79b, TCRzeta, FcRgamma, DAP12 and DAP10 genes in the Fugu genome was obtained. Furthermore, conserved synteny for the short regions including the TSS genes was revealed by comparison of the Fugu and human genomes. The data demonstrate that the set of TSSs arose before the teleost-tetrapod split and provide a starting point for experimental investigation of the molecular evolution of the leukocyte-activating receptor complexes from fish species to mammals.
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