ArticleImmunogenetics2003
Bioinformatic analysis of functional differences between the immunoproteasome and the constitutive proteasome.
Article in Immunogenetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Gemcitabine Modulates HLA-I Regulation to Improve Tumor Antigen Presentation by Pancreatic Cancer Cells.International journal of molecular sciences · 2024Article
- How gene duplication diversifies the landscape of protein oligomeric state and function.Current opinion in genetics & development · 2022Review
- Characterization of the Class I MHC Peptidome Resulting From DNCB Exposure of HaCaT Cells.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Immunoproteasome functions explained by divergence in cleavage specificity and regulation.eLife · 2017Article
- Role of peptide processing predictions in T cell epitope identification: contribution of different prediction programs.Immunogenetics · 2015Article
- Interferon-γ induces immunoproteasomes and the presentation of MHC I-associated peptides on human salivary gland cells.PloS one · 2014Article
- Computational prediction of cleavage using proteasomal in vitro digestion and MHC I ligand data.Journal of Zhejiang University. Science. B · 2013Article
- Proteome sampling by the HLA class I antigen processing pathway.PLoS computational biology · 2012Article
- Multi-scale modeling of tissues using CompuCell3D.Methods in cell biology · 2012Article
- Implications of CTL-mediated killing of HIV-infected cells during the non-productive stage of infection.PloS one · 2011Article
- Deletion of immunoproteasome subunits imprints on the transcriptome and has a broad impact on peptides presented by major histocompatibility complex I molecules.Molecular & cellular proteomics : MCP · 2010Article
- Transcriptional re-programming of primary macrophages reveals distinct apoptotic and anti-tumoral functions of IRF-3 and IRF-7.European journal of immunology · 2009Article
- Multicell simulations of development and disease using the CompuCell3D simulation environment.Methods in molecular biology (Clifton, N.J.) · 2009Article
- Characterization and phylogenetic analysis of a cnidarian LMP X-like cDNA.Immunogenetics · 2006Article
- The role of the proteasome in generating cytotoxic T-cell epitopes: insights obtained from improved predictions of proteasomal cleavage.Immunogenetics · 2005Article
- A mathematical model of protein degradation by the proteasome.Biophysical journal · 2005Article
- Natural selection during functional divergence to LMP7 and proteasome subunit X (PSMB5) following gene duplication.Journal of molecular evolution · 2005Article
- Discriminating self from nonself with short peptides from large proteomes.Immunogenetics · 2004Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular proteins are degraded largely by proteasomes. In cells stimulated with gamma interferon, the active proteasome subunits are replaced by "immuno" subunits that form immunoproteasomes. Phylogenetic analysis of the immunosubunits has revealed that they evolve faster than their constitutive counterparts. This suggests that the immunoproteasome has evolved a function that differs from that of the constitutive proteasome. Accumulating experimental degradation data demonstrate, indeed, that the specificity of the immunoproteasome and the constitutive proteasome differs. However, it has not yet been quantified how different the specificity of two forms of the proteasome are. The main question, which still lacks direct evidence, is whether the immunoproteasome generates more MHC ligands. Here we use bioinformatics tools to quantify these differences and show that the immunoproteasome is a more specific enzyme than the constitutive proteasome. Additionally, we predict the degradation of pathogen proteomes and find that the immunoproteasome generates peptides that are better ligands for MHC binding than peptides generated by the constitutive proteasome. Thus, our analysis provides evidence that the immunoproteasome has co-evolved with the major histocompatibility complex to optimize antigen presentation in vertebrate cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.