ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Reconsolidation of a long-term memory in Lymnaea requires new protein and RNA synthesis and the soma of right pedal dorsal 1.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- Reconsolidation of declarative memory in humans.Learning & memory (Cold Spring Harbor, N.Y.) · 2007Trial
- Aging disrupts transcriptional programs for memory updating in the dorsal hippocampus and reveals a required role forbioRxiv : the preprint server for biology · 2026Article
- Functional mapping of the molluscan brain guided by synchrotron X-ray tomography.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Distinct Proteomic Brain States Underlying Long-Term Memory Formation in Aversive Operant Conditioning.Journal of proteome research · 2025Article
- A flavonoid, quercetin, is capable of enhancing long-term memory formation if encountered at different times in the learning, memory formation, and memory recall continuum.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2022Article
- What can we teach Lymnaea and what can Lymnaea teach us?Biological reviews of the Cambridge Philosophical Society · 2021Review
- Understanding the dynamic and destiny of memories.Neuroscience and biobehavioral reviews · 2021Review
- Effect of photoperiod and light intensity on learning ability and memory formation of the pond snail Lymnaea stagnalis.Invertebrate neuroscience : IN · 2020Article
- Molecular Mechanisms of Reconsolidation-Dependent Memory Updating.International journal of molecular sciences · 2020Review
- Article
- Green tea and cocoa enhance cognition inCommunicative & integrative biology · 2018Article
- Impairing DNA methylation obstructs memory enhancement for at least 24 hours inCommunicative & integrative biology · 2017Article
- Impairment of the serotonergic neurons underlying reinforcement elicits extinction of the repeatedly reactivated context memory.Scientific reports · 2016Article
- Prediction of individual differences in fear response by novelty seeking, and disruption of contextual fear memory reconsolidation by ketamine.Neuropharmacology · 2016Article
- Transcription inhibitors prevent amnesia induced by NMDA antagonist-mediated impairment of memory reconsolidation.Learning & behavior · 2016Article
- Training Lymnaea in the presence of a predator scent results in a long-lasting ability to form enhanced long-term memory.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2016Article
- Inverse Relationship between Basal Pacemaker Neuron Activity and Aversive Long-Term Memory Formation inFrontiers in cellular neuroscience · 2016Article
- Reconsolidation and the Dynamic Nature of Memory.Cold Spring Harbor perspectives in biology · 2015Review
- The regulation of transcription in memory consolidation.Cold Spring Harbor perspectives in biology · 2014Review
- Allocating structure to function: the strong links between neuroplasticity and natural selection.Frontiers in human neuroscience · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reconsolidation of a long-term memory (LTM) in the snail Lymnaea stagnalis can be disrupted by cooling, an RNA synthesis blocker (actinomycin D), and by specifically ablating the soma of a cell we know is a site of LTM consolidation (right pedal dorsal 1, RPeD1). Aerial respiratory behavior was conditioned operantly by applying a gentle tactile stimulus to the pneumostome area (the respiratory orifice) every time the snail began to open its pneumostome to perform aerial respiration. This resulted in a reduction of this behavior while leaving cutaneous respiration intact. One week after training one-half of the animals received a memory reactivation session, which was similar to the original training (i.e., animals received reinforcement). All animals then received 1 hr of cooling, an injection of actinomycin D or saline, or the soma ablation procedure. This was followed by a test for savings 4 hr or 4 d later, which was also similar to the original training. Only those animals that received both the memory reactivation session and the treatment showed memory impairment during the test for savings. That is, the impairment was contingent on memory reactivation. These data indicate that reconsolidation requires both new RNA and protein synthesis to stabilize a reactivated memory, and it demonstrates that the soma of RPeD1, a cell that we have shown previously to be required in the consolidation of an LTM, is necessary for reconsolidation. These data suggest that the critical molecular processes occurring during both consolidation and reconsolidation transpire in the same cell in Lymnaea.
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12954865PMC6740499What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.