ArticleVirology2003
Epitope specificity is critical for high and moderate avidity cytotoxic T lymphocytes associated with control of viral load and clinical disease in horses with equine infectious anemia virus.
Article in Virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- A High-Coverage Epitope-Based Vaccine Design for EIAV Envelope Polyprotein Using an Immunoinformatic Approach.Veterinary sciences · 2026Article
- Development of a colloidal gold immunochromatographic strip to detect equine infectious anemia virus.Virology journal · 2025Article
- Key Factors and Parameter Ranges for Immune Control of Equine Infectious Anemia Virus Infection.Viruses · 2023Article
- Horses naturally infected with EIAV harbor 2 distinct SU populations but are monophyletic with respect to IN.Virus genes · 2016Article
- Epitope shifting of gp90-specific cellular immune responses in EIAV-infected ponies.Veterinary immunology and immunopathology · 2014Article
- The determination of in vivo envelope-specific cell-mediated immune responses in equine infectious anemia virus-infected ponies.Veterinary immunology and immunopathology · 2012Article
- Expression, refolding and preliminary X-ray crystallographic analysis of equine MHC class I molecule complexed with an EIAV-Env CTL epitope.Acta crystallographica. Section F, Structural biology and crystallization communications · 2012Article
- Protective effects of broadly neutralizing immunoglobulin against homologous and heterologous equine infectious anemia virus infection in horses with severe combined immunodeficiency.Journal of virology · 2011Article
- Rev variation during persistent lentivirus infection.Viruses · 2011Review
- Molecular detection, epidemiology, and genetic characterization of novel European field isolates of equine infectious anemia virus.Journal of clinical microbiology · 2011Article
- Selection of a rare neutralization-resistant variant following passive transfer of convalescent immune plasma in equine infectious anemia virus-challenged SCID horses.Journal of virology · 2010Article
- Viral load and clinical disease enhancement associated with a lentivirus cytotoxic T lymphocyte vaccine regimen.Vaccine · 2009Article
- Naturally arising point mutations in non-essential domains of equine infectious anemia virus Rev alter Rev-dependent nuclear-export activity.The Journal of general virology · 2008Article
- Envelope determinants of equine infectious anemia virus vaccine protection and the effects of sequence variation on immune recognition.Journal of virology · 2008Article
- Failure of low-dose recombinant human IL-2 to support the survival of virus-specific CTL clones infused into severe combined immunodeficient foals: lack of correlation between in vitro activity and in vivo efficacy.Veterinary immunology and immunopathology · 2008Article
- Article
- Dose-dependent modulation of CD8 and functional avidity as a result of peptide encounter.Immunology · 2007Article
- Cloning and large-scale expansion of epitope-specific equine cytotoxic T lymphocytes using an anti-equine CD3 monoclonal antibody and human recombinant IL-2.Veterinary immunology and immunopathology · 2007Article
- A single amino acid difference within the alpha-2 domain of two naturally occurring equine MHC class I molecules alters the recognition of Gag and Rev epitopes by equine infectious anemia virus-specific CTL.Journal of immunology (Baltimore, Md. : 1950) · 2006Article
- Evaluation of high functional avidity CTL to Gag epitope clusters in EIAV carrier horses.Virology · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Equine infectious anemia virus (EIAV) is a lentivirus that causes persistent infections in horses. We hypothesized that high-avidity CTL specific for nonvariable epitopes might be associated with low viral load and minimal disease in EIAV-infected horses. To test this hypothesis, memory CTL (CTLm) responses were analyzed in two infected horses with high plasma viral loads and recurrent disease (progressors), and in two infected horses with low-to-undetectable viral loads and mild disease (nonprogressors). High-avidity CTLm in one progressor recognized an envelope gp90 epitope, and the data documented for the first time in EIAV that viral variation led to CTL escape. Each of the nonprogressors had high-to-moderate avidity CTLm directed against epitopes within Rev, including the nuclear export and nuclear localization domains. These results suggested that the epitope specificity of high- and moderate-avidity CTLm was an important determinant for disease outcome in the EIAV-infected horses examined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.