ArticleThe Biochemical journal2003
Transcriptional regulation of methionine synthase by homocysteine and choline in Aspergillus nidulans.
Article in The Biochemical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Degradation of betaine aldehyde dehydrogenase transgenic maize BZ-136 straw and its effects on soil nutrients and fungal community.Frontiers in microbiology · 2023Article
- Identification and characterization of a bacterial core methionine synthase.Scientific reports · 2020Article
- Application of an antibody chip for screening differentially expressed proteins during peach ripening and identification of a metabolon in the SAM cycle to generate a peach ethylene biosynthesis model.Horticulture research · 2020Article
- Structure-guided function discovery of an NRPS-like glycine betaine reductase for choline biosynthesis in fungi.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Methionine synthase is localized to the nucleus inThe Journal of biological chemistry · 2017Article
- Exploration of Sulfur Assimilation of Aspergillus fumigatus Reveals Biosynthesis of Sulfur-Containing Amino Acids as a Virulence Determinant.Infection and immunity · 2016Article
- The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species.Microbiology and molecular biology reviews : MMBR · 2016Review
- Interplay between Gliotoxin Resistance, Secretion, and the Methyl/Methionine Cycle in Aspergillus fumigatus.Eukaryotic cell · 2015Article
- Inhibitors of amino acids biosynthesis as antifungal agents.Amino acids · 2015Review
- Phylogenetic analysis of methionine synthesis genes from Thalassiosira pseudonana.SpringerPlus · 2015Article
- Methionine biosynthesis is essential for infection in the rice blast fungus Magnaporthe oryzae.PloS one · 2015Article
- Serine O-acetyltransferase is important, but not essential for cysteine-methionine synthesis in Fusarium graminearum.World journal of microbiology & biotechnology · 2014Article
- Aspergillus nidulans genes encoding reverse transsulfuration enzymes belong to homocysteine regulon.Current genetics · 2009Article
- The gene for cobalamin-independent methionine synthase is essential in Candida albicans: a potential antifungal target.Archives of biochemistry and biophysics · 2007Article
- Interrelations between glycine betaine catabolism and methionine biosynthesis in Sinorhizobium meliloti strain 102F34.Journal of bacteriology · 2006Article
- Homocysteine- and cysteine-mediated growth defect is not associated with induction of oxidative stress response genes in yeast.The Biochemical journal · 2006Article
- Accumulation of homolanthionine and activation of a novel pathway for isoleucine biosynthesis in Corynebacterium glutamicum McbR deletion strains.Journal of bacteriology · 2006Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Roles played by homocysteine and choline in the regulation of MS (methionine synthase) have been examined in fungi. The Aspergillus nidulans metH gene encoding MS was cloned and characterized. Its transcription was not regulated by methionine, but was enhanced by homocysteine and repressed by choline and betaine. MS activity levels were regulated in a similar way. The repression by betaine was due to its metabolic conversion to choline, which was found to be very efficient in A. nidulans. Betaine and choline supplementation stimulated growth of leaky metH mutants apparently by decreasing the demand for methyl groups and thus saving methionine and S -adenosylmethionine. We have also found that homocysteine stimulates transcription of MS-encoding genes in Saccharomyces cerevisiae and Schizosaccharomyces pombe.
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