ArticleThe Journal of experimental medicine2003
Impaired T cell death and lupus-like autoimmunity in T cell-specific adapter protein-deficient mice.
Article in The Journal of experimental medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 66 citations in OpenAlex.
- Polygenic autoimmune disease risk alleles impacting B cell tolerance act in concert across shared molecular networks in mouse and in humans.Frontiers in immunology · 2022Review
- The peptide symporter SLC15a4 is essential for the development of systemic lupus erythematosus in murine models.PloS one · 2021Article
- The SH3 domains of the protein kinases ITK and LCK compete for adjacent sites on T cell-specific adapter protein.The Journal of biological chemistry · 2019Article
- T Cell-Specific Adaptor Protein Regulates Mitochondrial Function and CD4Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes.Nature communications · 2019Article
- Reduced MCMV Δm157 viral clearance in the absence of TSAd.Scientific reports · 2015Article
- The docking protein FRS2α is a critical regulator of VEGF receptors signaling.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Genetic variants in Arhgef11 are associated with kidney injury in the Dahl salt-sensitive rat.Hypertension (Dallas, Tex. : 1979) · 2012Article
- VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd.The Journal of experimental medicine · 2012Article
- SH2D2A modulates T cell mediated protection to a B cell derived tumor in transgenic mice.PloS one · 2012Article
- Genetic analysis of SH2D4A, a novel adapter protein related to T cell-specific adapter and adapter protein in lymphocytes of unknown function, reveals a redundant function in T cells.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Unravelling the association of partial T-cell immunodeficiency and immune dysregulation.Nature reviews. Immunology · 2008Review
- Cluster of systemic lupus erythematosus (SLE) associated with an oil field waste site: a cross sectional study.Environmental health : a global access science source · 2007Article
- Genetics of SLE in mice.Springer seminars in immunopathology · 2006Review
- Structure function analysis of SH2D2A isoforms expressed in T cells reveals a crucial role for the proline rich region encoded by SH2D2A exon 7.BMC immunology · 2006Article
- Microarray analysis of mercury-induced changes in gene expression in human liver carcinoma (HepG2) cells: importance in immune responses.International journal of environmental research and public health · 2006Article
- Essential role of the T cell-specific adapter protein in the activation of LCK in peripheral T cells.The Journal of experimental medicine · 2006Article
- T-helper cell intrinsic defects in lupus that break peripheral tolerance to nuclear autoantigens.Journal of molecular medicine (Berlin, Germany) · 2005Review
- cDNA cloning of a rat orthologue of SH2D2A encoding T-cell-specific adaptor protein (TSAd): expression in T and NK cells.Immunogenetics · 2004Article
- Genetic association between juvenile rheumatoid arthritis and polymorphism in the SH2D2A gene.Genes and immunity · 2004Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
T cell-specific adaptor protein (TSAd) is a T lineage-restricted signaling adaptor molecule that is thought to participate in the assembly of intracellular signaling complexes in T cells. Previous studies of TSAd-deficient mice have revealed a role for TSAd in the induction of T cell interleukin 2 secretion and proliferation. We now show that TSAd-deficient mice are susceptible to lupus-like autoimmune disease. On the nonautoimmune-prone C57BL/6 genetic background, TSAd deficiency results in hypergammaglobulinemia that affects all immunoglobulin (Ig)G subclasses. Older C57BL/6 TSAd-deficient mice (1 yr of age) accumulate large numbers of activated T and B cells in spleen, produce autoantibodies against a variety of self-targets including single stranded (ss) and double stranded (ds) DNA, and, in addition, develop glomerulonephritis. We further show that immunization of younger C57BL/6 TSAd-deficient mice (at age 2 mo) with pristane, a recognized nonspecific inflammatory trigger of lupus, results in more severe glomerulonephritis compared with C57BL/6 controls and the production of high titer ss and ds DNA antibodies of the IgG subclass that are not normally produced by C57BL/6 mice in this model. The development of autoimmunity in TSAd-deficient mice is associated with defective T cell death in vivo. These findings illustrate the role of TSAd as a critical regulator of T cell death whose absence promotes systemic autoimmunity.
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Registered trials
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