ArticleThe Journal of clinical investigation2003
Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning.
Article in The Journal of clinical investigation, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 84 citations in OpenAlex.
- CXCR4 antagonism corrects neutrophil abnormalities and reduces pneumonia severity in a pharmacological mouse model of CXCR2 loss-of-function-mediated neutropenia.Frontiers in immunology · 2025Article
- Antibody Conditioning Enables MHC-Mismatched Hematopoietic Stem Cell Transplants and Organ Graft Tolerance.Cell stem cell · 2019Article
- Signal one and two blockade are both critical for non-myeloablative murine HSCT across a major histocompatibility complex barrier.PloS one · 2013Article
- Regulatory T-cell subset analysis and profile of interleukin (IL)-10, IL-17 and interferon-gamma cytokine-producing cells in kidney allograft recipients with donor cells infusion.Clinical and experimental nephrology · 2012Article
- T-cell activation and transplantation tolerance.Transplantation reviews (Orlando, Fla.) · 2012Review
- Translating tolerogenic therapies to the clinic - where do we stand?Frontiers in immunology · 2012Article
- Ursolic acid promotes robust tolerance to cardiac allografts in mice.Clinical and experimental immunology · 2011Article
- Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease.Seminars in immunopathology · 2011Review
- Treg-therapy allows mixed chimerism and transplantation tolerance without cytoreductive conditioning.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2010Article
- TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance.Blood · 2009Article
- Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response.Cell stress & chaperones · 2008Article
- TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance.Annals of the New York Academy of Sciences · 2008Article
- Murine mobilized peripheral blood stem cells have a lower capacity than bone marrow to induce mixed chimerism and tolerance.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2008Article
- Rapid deletional peripheral CD8 T cell tolerance induced by allogeneic bone marrow: role of donor class II MHC and B cells.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Manipulating the immune system for anti-tumor responses and transplant tolerance via mixed hematopoietic chimerism.Immunological reviews · 2008Review
- Induction of transplantation tolerance by combining non-myeloablative conditioning with delivery of alloantigen by T cells.Clinical immunology (Orlando, Fla.) · 2008Article
- Viral infection: a potent barrier to transplantation tolerance.Clinical & developmental immunology · 2008Review
- CTLA4Ig promotes the induction of hematopoietic chimerism and tolerance independently of Indoleamine-2,3-dioxygenase.Transplantation · 2007Article
- Elimination of insulitis and augmentation of islet beta cell regeneration via induction of chimerism in overtly diabetic NOD mice.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Allogeneic hematopoietic chimerism leading to central tolerance has significant therapeutic potential. Realization of that potential has been impeded by the need for myeloablative conditioning of the host and development of graft-versus-host disease (GVHD). To surmount these impediments, we have adapted a costimulation blockade-based protocol developed for solid organ transplantation for use in stem cell transplantation. The protocol combines donor-specific transfusion (DST) with anti-CD154 mAb. When applied to stem cell transplantation, administration of DST, anti-CD154 mAb, and allogeneic bone marrow leads to hematopoietic chimerism and central tolerance with no myeloablation and no GVHD. Tolerance in this system results from deletion of both peripheral host alloreactive CD8+ T cells and nascent intrathymic alloreactive CD8+ T cells. In the absence of large numbers of host alloreactive CD8+ T cells, the transfusion that precedes transplantation need not be of donor origin, suggesting that both allospecific and non-allospecific mechanisms regulate engraftment. Agents that interfere with peripheral transplantation tolerance impair establishment of chimerism. We conclude that robust allogeneic hematopoietic chimerism and central tolerance can be established in the absence of host myeloablative conditioning using a peripheral transplantation tolerance protocol.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.