ArticleGenome research2003
Pleiotropy, homeostasis, and functional networks based on assays of cardiovascular traits in genetically randomized populations.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose.PLoS genetics · 2022Article
- Gender-specific characteristics of hypertrophic response in cardiomyocytes derived from human embryonic stem cells.Journal of cardiovascular and thoracic research · 2021Article
- Cardiometabolic-Based Chronic Disease, Adiposity and Dysglycemia Drivers: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2020Review
- Field cricket genome reveals the footprint of recent, abrupt adaptation in the wild.Evolution letters · 2020Article
- The virtuous cycle of human genetics and mouse models in drug discovery.Nature reviews. Drug discovery · 2019Review
- Identification of self-regulatory network motifs in reverse engineering gene regulatory networks using microarray gene expression data.IET systems biology · 2019Article
- Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face.Scientific reports · 2018Article
- Canalization Leads to Similar Whole Bone Mechanical Function at Maturity in Two Inbred Strains of Mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Contrasting genetic architectures in different mouse reference populations used for studying complex traits.Genome research · 2015Review
- Functional network analysis of obese and lean Göttingen minipigs elucidates changes in oxidative and inflammatory networks in obese pigs.Pflugers Archiv : European journal of physiology · 2014Article
- Article
- Effect of chromosome substitution on intrinsic exercise capacity in mice.F1000Research · 2014Article
- Systematic evaluation of skeletal mechanical function.Current protocols in mouse biology · 2013Article
- Chromosome substitution strains: gene discovery, functional analysis, and systems studies.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Review
- Systems-based approaches to cardiovascular disease.Nature reviews. Cardiology · 2012Review
- A genome-wide linkage scan for quantitative trait loci influencing the craniofacial complex in humans (Homo sapiens sapiens).Anatomical record (Hoboken, N.J. : 2007) · 2011Article
- Genetics. Systems genetics.Science (New York, N.Y.) · 2011Article
- Review
- Phenotypic integration among trabecular and cortical bone traits establishes mechanical functionality of inbred mouse vertebrae.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2009Article
- Phenotypic integration of skeletal traits during growth buffers genetic variants affecting the slenderness of femora in inbred mouse strains.Mammalian genome : official journal of the International Mammalian Genome Society · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
A major problem in studying biological traits is understanding how genes work together to provide organismal structures and functions. Conventional reductionist paradigms attribute functions to particular proteins, motifs, and amino acids. An equally important but harder problem involves the synthesis of data at fundamental levels of biological systems to understand functionality at higher levels. We used subtle, naturally occurring, multigenic variation of cardiovascular (CV) properties in a panel of genetically randomized strains that are derived from the A/J and C57BL/6J strains of mice to perturb CV functions in nonpathologic ways. In this proof-of-concept study, computational analysis correctly identified the known relations among CV properties and revealed functionality at higher levels of the CV system. The network was then used to account for pleiotropies and homeostatic responses in single gene mutant mice and in mice treated with a pharmacologic agent (anesthesia). The CV network accounted for functional dependencies in complementary ways to the insights obtained from genetic networks and biochemical pathways. These networks are therefore an important approach for defining and characterizing functional relations in complex biological systems in health and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.