ArticleGenome research2003
Application of DNA microarrays to study the evolutionary genomics of Yersinia pestis and Yersinia pseudotuberculosis.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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Who cites it
73 citing papers in PubMed.
- Complete structures of the YenTc holotoxin prepore and pore reveal the evolutionary basis for chitinase incorporation into ABC toxins.Nature communications · 2025Article
- Review
- Recent insights into mechanisms of cellular toxicity and cell recognition associated with the ABC family of pore-forming toxins.Biochemical Society transactions · 2023Article
- A frameshift ineLife · 2023Article
- Common architecture of Tc toxins from human and insect pathogenic bacteria.Science advances · 2019Article
- Pan-genomic analyses identify keyGut · 2018Article
- Review
- Article
- A mutant with aberrant extracellular LcrV-YscF interactions fails to form pores and translocate Yop effector proteins but retains the ability to trigger Yop secretion in response to host cell contact.Journal of bacteriology · 2013Article
- A multi-omic systems approach to elucidating Yersinia virulence mechanisms.Molecular bioSystems · 2013Article
- Rational considerations about development of live attenuated Yersinia pestis vaccines.Current pharmaceutical biotechnology · 2013Review
- Evolution and virulence contributions of the autotransporter proteins YapJ and YapK of Yersinia pestis CO92 and their homologs in Y. pseudotuberculosis IP32953.Infection and immunity · 2012Article
- Evolutionary insights into scleractinian corals using comparative genomic hybridizations.BMC genomics · 2012Article
- Cluster analysis of host cytokine responses to biodefense pathogens in a whole blood ex vivo exposure model (WEEM).BMC microbiology · 2012Article
- Expression during host infection and localization of Yersinia pestis autotransporter proteins.Journal of bacteriology · 2011Article
- Array CGH phylogeny: how accurate are comparative genomic hybridization-based trees?BMC genomics · 2011Article
- Array Comparative Genomic Hybridizations: assessing the ability to recapture evolutionary relationships using an in silico approach.BMC genomics · 2011Article
- Identification and characterisation of a novel adhesin Ifp in Yersinia pseudotuberculosis.BMC microbiology · 2011Article
- Targeting of the actin cytoskeleton by insecticidal toxins from Photorhabdus luminescens.Naunyn-Schmiedeberg's archives of pharmacology · 2011Review
- High-throughput microarray technology in diagnostics of enterobacteria based on genome-wide probe selection and regression analysis.BMC genomics · 2010Article
13 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
Funding
Abstract
Yersinia pestis, the causative agent of plague, diverged from Yersinia pseudotuberculosis, an enteric pathogen, an estimated 1500-20,000 years ago. Genetic characterization of these closely related organisms represents a useful model to study the rapid emergence of bacterial pathogens that threaten mankind. To this end, we undertook genome-wide DNA microarray analysis of 22 strains of Y. pestis and 10 strains of Y. pseudotuberculosis of diverse origin. Eleven Y. pestis DNA loci were deemed absent or highly divergent in all strains of Y. pseudotuberculosis. Four were regions of phage origin, whereas the other seven included genes encoding a vitamin B12 receptor and the insect toxin sepC. Sixteen differences were identified between Y. pestis strains, with biovar Antiqua and Mediaevalis strains showing most divergence from the arrayed CO92 Orientalis strain. Fifty-eight Y. pestis regions were specific to a limited number of Y. pseudotuberculosis strains, including the high pathogenicity island, three putative autotransporters, and several possible insecticidal toxins and hemolysins. The O-antigen gene cluster and one of two possible flagellar operons had high levels of divergence between Y. pseudotuberculosis strains. This study reports chromosomal differences between species, biovars, serotypes, and strains of Y. pestis and Y. pseudotuberculosis that may relate to the evolution of these species in their respective niches.
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