ArticleProceedings. Biological sciences2003
Shaker K(+)-channels are predicted to reduce the metabolic cost of neural information in Drosophila photoreceptors.
Article in Proceedings. Biological sciences, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Homeostatic regulation of neuronal function: importance of degeneracy and pleiotropy.Frontiers in cellular neuroscience · 2023Review
- Modulation of voltage-dependent K+ conductances in photoreceptors trades off investment in contrast gain for bandwidth.PLoS computational biology · 2018Article
- On the role of transient depolarization-activated KThe Journal of general physiology · 2018Article
- Physiological and ecological implications of ocean deoxygenation for vision in marine organisms.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2017Review
- Voltage-dependent KJournal of the Royal Society, Interface · 2017Article
- Static and Dynamic Adaptation of Insect Photoreceptor Responses to Naturalistic Stimuli.Frontiers in physiology · 2016Article
- Performance of blue- and green-sensitive photoreceptors of the cricket Gryllus bimaculatus.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2014Article
- Information and efficiency in the nervous system--a synthesis.PLoS computational biology · 2013Review
- Serotonin circuits and anxiety: what can invertebrates teach us?Invertebrate neuroscience : IN · 2012Review
- Postembryonic developmental changes in photoreceptors of the stick insect Carausius morosus enhance the shift to an adult nocturnal life-style.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Cellular elements for seeing in the dark: voltage-dependent conductances in cockroach photoreceptors.BMC neuroscience · 2012Article
- Energy-based stochastic control of neural mass models suggests time-varying effective connectivity in the resting state.Journal of computational neuroscience · 2012Article
- Brain organization mirrors caste differences, colony founding and nest architecture in paper wasps (Hymenoptera: Vespidae).Proceedings. Biological sciences · 2009Article
- ATP consumption by mammalian rod photoreceptors in darkness and in light.Current biology : CB · 2008Article
- Article
- Robustness of neural coding in Drosophila photoreceptors in the absence of slow delayed rectifier K+ channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Channelling evolution: canalization and the nervous system.PLoS biology · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shaker K(+)-channels are one of several voltage-activated K(+)-channels expressed in Drosophila photoreceptors. We have shown recently that Shaker channels act as selective amplifiers, attenuating some signals while boosting others. Loss of these channels reduces the photoreceptor information capacity (bits s(-1)) and induces compensatory changes in photoreceptors enabling them to minimize the impact of this loss upon coding natural-like stimuli. Energy as well as coding is also an important consideration in understanding the role of ion channels in neural processing. Here, we use a simple circuit model that incorporates the major ion channels, pumps and exchangers of the photoreceptors to derive experimentally based estimates of the metabolic cost of neural information in wild-type (WT) and Shaker mutant photoreceptors. We show that in WT photoreceptors, which contain Shaker K(+)-channels, each bit of information costs approximately half the number of ATP molecules than each bit in Shaker photoreceptors, in which lack of the Shaker K(+)-channels is compensated by increased leak conductance. Additionally, using a Hodgkin-Huxley-type model coupled to the circuit model we show that the amount of leak present in both WT and Shaker photoreceptors is optimized to both maximize the available voltage range and minimize the metabolic cost.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.