ArticleJournal of muscle research and cell motility2002
Chaperonin 60 and mitochondrial disease in Dictyostelium.
Article in Journal of muscle research and cell motility, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Non-Mammalian Models for Mitochondria Research in CNS Disorders.Biomolecules · 2026Review
- Polycystin-2 Mediated Calcium Signalling in theCells · 2024Article
- Plate-Based Assays for the Characterization of Mitochondrial and Cellular Phenotypes.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Generation of a mitochondrial protein compendium iniScience · 2022Article
- TheFrontiers in cell and developmental biology · 2022Article
- Chronic Activation of AMPK Induces Mitochondrial Biogenesis through Differential Phosphorylation and Abundance of Mitochondrial Proteins inInternational journal of molecular sciences · 2021Article
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- The Parkinson's disease-associated protein DJ-1 plays a positive nonmitochondrial role in endocytosis inDisease models & mechanisms · 2017Article
- Specific growth suppression of human cancer cells by targeted delivery of Dictyostelium mitochondrial ribosomal protein S4.Cancer cell international · 2014Article
- Control of cell differentiation by mitochondria, typically evidenced in dictyostelium development.Biomolecules · 2013Article
- The green tea catechin epigallocatechin gallate (EGCG) blocks cell motility, chemotaxis and development in Dictyostelium discoideum.PloS one · 2013Article
- A genetic interaction between NDPK and AMPK in Dictyostelium discoideum that affects motility, growth and development.Naunyn-Schmiedeberg's archives of pharmacology · 2011Article
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- Dictyostelium discoideum--a model for many reasons.Molecular and cellular biochemistry · 2009Review
- Diverse cytopathologies in mitochondrial disease are caused by AMP-activated protein kinase signaling.Molecular biology of the cell · 2007Article
- Import-associated translational inhibition: novel in vivo evidence for cotranslational protein import into Dictyostelium discoideum mitochondria.Eukaryotic cell · 2006Article
- Cloning and characterization of the mitochondrial heat-shock protein 60 gene of Trichinella spiralis.Parasitology research · 2004Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The single Dictyostelium chaperonin 60 gene, hspA, was cloned, sequenced and characterized. Sequence comparisons and a three-dimensional model for the structure of the encoded protein showed that it exhibits the conserved sequence and structural features expected for its role as the Dictyostelium mitochondrial chaperonin 60. Dictyostelium hspA contains two introns and, unusually for a member of this major heat shock gene family, is not stress-inducible in response to heat, cold or cadmium ions. Although transcription of hspA is down regulated during early Dictyostelium development in response to starvation, the levels of the chaperonin 60 protein remain constant throughout the life cycle. Consistent with the essential role of chaperonin 60 in mitochondrial biogenesis, we were unable to isolate mutants in which the hspA gene had been disrupted. However, transformants were isolated that exhibited differing levels of antisense inhibition of chaperonin 60 expression, depending upon the number of copies of the antisense-expressing plasmid in the genome. Orientation in phototaxis (and thermotaxis) was severely impaired in all antisense transformants, while growth and morphogenesis were markedly defective only in transformants with higher levels of antisense inhibition. This pattern of phenotypes is similar to that reported previously to result from targeted disruption of the mitochondrial large subunit rRNA gene in a subpopulation of mitochondria. This suggests that, regardless of the nature of the underlying genetic defect, mitochondrial deficiency impairs signal transduction more sensitively than other cellular activities.
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