ArticleJournal of muscle research and cell motility2002
The actin-bundling protein cortexillin is the downstream target of a Rac1-signaling pathway required for cytokinesis.
Article in Journal of muscle research and cell motility, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression.Developmental cell · 2011Article
- Dynamic localization of the actin-bundling protein cortexillin I during cell migration.Molecules and cells · 2011Article
- Regulation of Rap1 activity by RapGAP1 controls cell adhesion at the front of chemotaxing cells.The Journal of cell biology · 2007Article
- GxcDD, a putative RacGEF, is involved in Dictyostelium development.BMC cell biology · 2007Article
- A Rab21/LIM-only/CH-LIM complex regulates phagocytosis via both activating and inhibitory mechanisms.The EMBO journal · 2005Article
- Dictyostelium LIS1 is a centrosomal protein required for microtubule/cell cortex interactions, nucleus/centrosome linkage, and actin dynamics.Molecular biology of the cell · 2005Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the process of cytokinesis by which eukaryotic cells constrict and divide in two, multiple cellular activities have to be precisely coordinated in space and time to guarantee equal distribution of chromosomes and cytoplasm to the emerging daughter cells. Eventually, constriction of the cleavage furrow leads to the complete separation of the daughter cells. Since the basic observation of cell division some 100 years ago, the principal challenge has been to unravel the detailed molecular mechanisms and signaling events leading to cytokinesis. Regulation of this fundamental cellular process is still poorly understood yet a central issue in modern cell biology. In the recent past it became evident that small GTPases of the Ras super family play a major role during this process. This review is focused on a Rho family GTPase-mediated signaling pathway that is required for cleavage furrow assembly and cytokinesis by the actin-bundling protein cortexillin of D. discoideum cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.