ReviewJournal of muscle research and cell motility2002
A contextual framework for characterizing motility and chemotaxis mutants in Dictyostelium discoideum.
Review in Journal of muscle research and cell motility, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
- Diverse and dynamic sources and sinks in gradient formation and directed migration.Current opinion in cell biology · 2014Review
- Myosin heavy chain kinases play essential roles in Ca2+, but not cAMP, chemotaxis and the natural aggregation of Dictyostelium discoideum.Journal of cell science · 2012Article
- The IplA Ca2+ channel of Dictyostelium discoideum is necessary for chemotaxis mediated through Ca2+, but not through cAMP, and has a fundamental role in natural aggregation.Journal of cell science · 2012Article
- A quorum-sensing factor in vegetative Dictyostelium discoideum cells revealed by quantitative migration analysis.PloS one · 2011Article
- External and internal constraints on eukaryotic chemotaxis.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Cell speed, persistence and information transmission during signal relay and collective migration.Journal of cell science · 2010Article
- How a cell crawls and the role of cortical myosin II.Eukaryotic cell · 2009Article
- The effects of extracellular calcium on motility, pseudopod and uropod formation, chemotaxis, and the cortical localization of myosin II in Dictyostelium discoideum.Cell motility and the cytoskeleton · 2009Article
- tsunami, the Dictyostelium homolog of the Fused kinase, is required for polarization and chemotaxis.Genes & development · 2008Article
- Oscillatory signaling and network responses during the development of Dictyostelium discoideum.Ageing research reviews · 2008Review
- Directional sensing during chemotaxis.FEBS letters · 2008Review
- Exploring the control circuit of cell migration by mathematical modeling.Biophysical journal · 2008Article
- The regulation of cell motility and chemotaxis by phospholipid signaling.Journal of cell science · 2008Review
- Arachidonic acid is a chemoattractant for Dictyostelium discoideum cells.Journal of biosciences · 2007Article
- Biased random walk by stochastic fluctuations of chemoattractant-receptor interactions at the lower limit of detection.Biophysical journal · 2007Article
- Nonadaptive regulation of ERK2 in Dictyostelium: implications for mechanisms of cAMP relay.Molecular biology of the cell · 2006Article
- Multiple myosin II heavy chain kinases: roles in filament assembly control and proper cytokinesis in Dictyostelium.Molecular biology of the cell · 2005Article
- Intracellular role of adenylyl cyclase in regulation of lateral pseudopod formation during Dictyostelium chemotaxis.Eukaryotic cell · 2005Article
- Phg2, a kinase involved in adhesion and focal site modeling in Dictyostelium.Molecular biology of the cell · 2004Article
- RasC plays a role in transduction of temporal gradient information in the cyclic-AMP wave of Dictyostelium discoideum.Eukaryotic cell · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In the natural aggregation process, Dictyostelium amoebae relay the cAMP signal outwardly through the cell population as symmetric, nondissipating waves. Each cell in turn responds in a specific manner to the different phases of the wave. In the front of each wave, each cell experiences an increasing temporal gradient and positive spatial gradient of cAMP; at the peak of each wave, each cell experiences a cAMP concentration inhibitory to locomotion; and in the back of each wave, each cell experiences a decreasing temporal and negative spatial gradient of cAMP. Protocols are described to analyze the basic motile behavior of mutant cells in the absence of a chemotactic signal, and to test the responsiveness of mutant cells to the individual temporal, spatial and concentration components of a natural wave. The results of such an analysis can then be used to develop realistic models of cell motility and chemotaxis. Examples are described in which this contextual framework has been applied to mutant cell lines. The results of these mutant studies result in a model in which independent parallel regulatory pathways emanating from different phases of the wave effect different phase-specific behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.