ArticleJournal of bacteriology2003
Complete genome sequence of the oral pathogenic Bacterium porphyromonas gingivalis strain W83.
Article in Journal of bacteriology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 234 papers.
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Who cites it
234 citing papers in PubMed, 382 citations in OpenAlex.
- A DPP inhibitor suppresses periodontitis via antibacterial effect targeting Porphyromonas gingivalis.Scientific reports · 2026Article
- Porphyromonas gingivalis produces a functional HemH ferrochelatase important for its survival in a heme-limited environment.Scientific reports · 2026Article
- The survival status ofJournal of oral microbiology · 2026Review
- Macrophage activation and invasion byJournal of oral microbiology · 2026Article
- Virulence diversity amongJournal of oral microbiology · 2026Review
- Biochemical and functional characterization ofFrontiers in microbiology · 2026Article
- Machine learning-guided discovery of thermophilic carbonic anhydrases from environmental metagenomes.Scientific reports · 2025Article
- Role of CRISPR-Cas systems in periodontal disease pathogenesis and potential for periodontal therapy: A review.Molecular oral microbiology · 2025Review
- Lipid a remodeling modulates outer membrane vesicle biogenesis byJournal of bacteriology · 2025Article
- In Vitro Infection of Human Macrophages withInternational journal of molecular sciences · 2025Article
- Exploring heme and iron acquisition strategies of Porphyromonas gingivalis-current facts and hypotheses.FEMS microbiology reviews · 2025Review
- TheJournal of oral microbiology · 2025Article
- In vitro study of probiotic Lactobacillus helveticus: Antibacterial effects on Porphyromonas gingivalis.PloS one · 2025Article
- The Effect of Oral Care Product Ingredients on Oral Pathogenic Bacteria Transcriptomics Through RNA-Seq.Microorganisms · 2024Article
- The Oral Microbial Ecosystem in Age-Related Xerostomia: A Critical Review.International journal of molecular sciences · 2024Review
- First crystal structure of the DUF2436 domain of virulence proteins from Porphyromonas gingivalis.Acta crystallographica. Section F, Structural biology communications · 2024Article
- Do high-protein diets have the potential to reduce gut barrier function in a sex-dependent manner?European journal of nutrition · 2024Article
- Metagenome-derived SusD-homologs affiliated with Bacteroidota bind to synthetic polymers.Applied and environmental microbiology · 2024Article
- A pleiotropic role of sialidase in the pathogenicity ofInfection and immunity · 2024Article
- Comparative analysis ofMicrobiology spectrum · 2024Article
174 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
23 authors.
Funding
Abstract
The complete 2,343,479-bp genome sequence of the gram-negative, pathogenic oral bacterium Porphyromonas gingivalis strain W83, a major contributor to periodontal disease, was determined. Whole-genome comparative analysis with other available complete genome sequences confirms the close relationship between the Cytophaga-Flavobacteria-Bacteroides (CFB) phylum and the green-sulfur bacteria. Within the CFB phyla, the genomes most similar to that of P. gingivalis are those of Bacteroides thetaiotaomicron and B. fragilis. Outside of the CFB phyla the most similar genome to P. gingivalis is that of Chlorobium tepidum, supporting the previous phylogenetic studies that indicated that the Chlorobia and CFB phyla are related, albeit distantly. Genome analysis of strain W83 reveals a range of pathways and virulence determinants that relate to the novel biology of this oral pathogen. Among these determinants are at least six putative hemagglutinin-like genes and 36 previously unidentified peptidases. Genome analysis also reveals that P. gingivalis can metabolize a range of amino acids and generate a number of metabolic end products that are toxic to the human host or human gingival tissue and contribute to the development of periodontal disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.