ArticleJournal of bacteriology2003
A dual binding site for integration host factor and the response regulator CtrA inside the Caulobacter crescentus replication origin.
Article in Journal of bacteriology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- The noncoding RNA CcnA modulates the master cell cycle regulators CtrA and GcrA in Caulobacter crescentus.PLoS biology · 2022Article
- Computational modeling of unphosphorylated CtrA:iScience · 2021Article
- Multilayered control of chromosome replication inBiochemical Society transactions · 2019Review
- The Temporal Expression of Global Regulator Protein CsrA Is Dually Regulated by ClpP During the Biphasic Life Cycle ofFrontiers in microbiology · 2019Article
- Sensory domain of the cell cycle kinase CckA regulates the differential DNA binding of the master regulator CtrA in Caulobacter crescentus.Biochimica et biophysica acta. Gene regulatory mechanisms · 2018Article
- Defining the Functionally Important Domain and Amino Acid Residues in Mycobacterium tuberculosis Integration Host Factor for Genome Stability, DNA Binding, and Integrative Recombination.Journal of bacteriology · 2017Article
- Use of a Phosphorylation Site Mutant To Identify Distinct Modes of Gene Repression by the Control of Virulence Regulator (CovR) in Streptococcus pyogenes.Journal of bacteriology · 2017Article
- Replication fork passage drives asymmetric dynamics of a critical nucleoid-associated protein in Caulobacter.The EMBO journal · 2017Article
- Targeting the Bacterial Orisome in the Search for New Antibiotics.Frontiers in microbiology · 2017Article
- VAP, a Versatile Access Point for the Endoplasmic Reticulum: Review and analysis of FFAT-like motifs in the VAPome.Biochimica et biophysica acta · 2016Review
- Redefining bacterial origins of replication as centralized information processors.Frontiers in microbiology · 2015Review
- Maintenance of chromosome structure in Pseudomonas aeruginosa.FEMS microbiology letters · 2014Review
- oriC-encoded instructions for the initiation of bacterial chromosome replication.Frontiers in microbiology · 2014Review
- Mycobacterium tuberculosis origin of replication and the promoter for immunodominant secreted antigen 85B are the targets of MtrA, the essential response regulator.The Journal of biological chemistry · 2010Article
- Getting in the loop: regulation of development in Caulobacter crescentus.Microbiology and molecular biology reviews : MMBR · 2010Review
- Synchronization of chromosome dynamics and cell division in bacteria.Cold Spring Harbor perspectives in biology · 2010Review
- Correct timing of dnaA transcription and initiation of DNA replication requires trans translation.Journal of bacteriology · 2009Article
- Reciprocal expression of integration host factor and HU in the developmental cycle and infectivity of Legionella pneumophila.Applied and environmental microbiology · 2009Article
- Complex regulatory pathways coordinate cell-cycle progression and development in Caulobacter crescentus.Advances in microbial physiology · 2009Review
- DnaA couples DNA replication and the expression of two cell cycle master regulators.The EMBO journal · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The response regulator CtrA controls chromosome replication by binding to five sites, a, b, c, d, and e, inside the Caulobacter crescentus replication origin (Cori). In this study, we demonstrate that integration host factor (IHF) binds Cori over the central CtrA binding site c. Surprisingly, IHF and CtrA share DNA recognition sequences. Rather than promoting cooperative binding, IHF binding hinders CtrA binding to site c and nearby site d. Unlike other CtrA binding sites, DNA mutations in the CtrA c/IHF site uniquely impair autonomous Cori plasmid replication. These mutations also alter transcription from distant promoters more than 100 bp away. When the CtrA c/IHF site was deleted from the chromosome, these cells grew slowly and became selectively intolerant to a CtrA phosphor-mimic allele (D51E). Since CtrA protein concentration decreases during the cell cycle as IHF protein concentration increases, we propose a model in which IHF displaces CtrA in order to bend Cori and promote efficient chromosome replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.