ArticleEnvironmental health perspectives2003
Elevated nitric oxide/peroxynitrite theory of multiple chemical sensitivity: central role of N-methyl-D-aspartate receptors in the sensitivity mechanism.
Article in Environmental health perspectives, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS).International journal of environmental research and public health · 2021Pooled it
- Perspectives on multisensory perception disruption in idiopathic environmental intolerance: a systematic review.International archives of occupational and environmental health · 2018Pooled it
- Exploratory Investigation of a Brief Cognitive Behavioral Intervention and Transcranial Direct Current Stimulation on Odor Sensitivity.Psychosomatic medicine · 2019Trial
- Chemosensory perception, symptoms and autonomic responses during chemical exposure in multiple chemical sensitivity.International archives of occupational and environmental health · 2016Trial
- How pandemics reshape our brain: Common links and targets between long-haul COVID-19, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), oxidative stress, and neurodegeneration.Neuroprotection (Chichester, England) · 2025Article
- Identification of CD8 T-cell dysfunction associated with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Long COVID and treatment with a nebulized antioxidant/anti-pathogen agent in a retrospective case series.Brain, behavior, & immunity - health · 2024Article
- Combined Neurological Syndrome in Electrohypersensitivity and Multiple Chemical Sensitivity: A Clinical Study of 2018 Cases.Journal of clinical medicine · 2023Article
- Multiple Chemical Sensitivity.Brain sciences · 2021Review
- Effect of Radiofrequency Electromagnetic Fields on Thermal Sensitivity in the Rat.International journal of environmental research and public health · 2020Article
- Multiple Chemical Sensitivity Syndrome: A Principal Component Analysis of Symptoms.International journal of environmental research and public health · 2020Article
- The SNP rs2298383 Reduces ADORA2A Gene Transcription and Positively Associates with Cytokine Production by Peripheral Blood Mononuclear Cells in Patients with Multiple Chemical Sensitivity.International journal of molecular sciences · 2020Article
- Article
- How Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Progresses: The Natural History of ME/CFS.Frontiers in neurology · 2020Article
- Olfactory-Related Quality of Life in Multiple Chemical Sensitivity: A Genetic-Acquired Factors Model.International journal of molecular sciences · 2019Article
- Safety and tolerability of sauna detoxification for the protracted withdrawal symptoms of substance abuse.The Journal of international medical research · 2018Article
- A Molecular Neurobiological Approach to Understanding the Aetiology of Chronic Fatigue Syndrome (Myalgic Encephalomyelitis or Systemic Exertion Intolerance Disease) with Treatment Implications.Molecular neurobiology · 2018Review
- Severe Adverse Reactions Following Ketoconazole, Fluconazole, and Environmental Exposures: A Case Report.Drug safety - case reports · 2018Article
- The Neuroinflammatory Etiopathology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).Frontiers in physiology · 2017Article
- Multidimensional assessment of self-reported chemical intolerance and its impact on chemosensory effects during ammonia exposure.International archives of occupational and environmental health · 2016Article
- Role of polymorphisms of inducible nitric oxide synthase and endothelial nitric oxide synthase in idiopathic environmental intolerances.Mediators of inflammation · 2015Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The elevated nitric oxide/peroxynitrite and the neural sensitization theories of multiple chemical sensitivity (MCS) are extended here to propose a central mechanism for the exquisite sensitivity to organic solvents apparently induced by previous chemical exposure in MCS. This mechanism is centered on the activation of N-methyl-D-aspartate (NMDA) receptors by organic solvents producing elevated nitric oxide and peroxynitrite, leading in turn to increased stimulating of and hypersensitivity of NMDA receptors. In this way, organic solvent exposure may produce progressive sensitivity to organic solvents. Pesticides such as organophosphates and carbamates may act via muscarinic stimulation to produce a similar biochemical and sensitivity response. Accessory mechanisms of sensitivity may involve both increased blood-brain barrier permeability, induced by peroxynitrite, and cytochrome P450 inhibition by nitric oxide. The NMDA hyperactivity/hypersensitivity and excessive nitric oxide/peroxynitrite view of MCS provides answers to many of the most puzzling aspects of MCS while building on previous studies and views of this condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.