ArticlePediatric cardiology
Chromosome 22q11 deletion in patients with truncus arteriosus.
Article in Pediatric cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 72 citations in OpenAlex.
- Case report of rare congenital cardiovascular anomalies associated with truncus arteriosus type 2.Heliyon · 2022Article
- Role of CT in the Pre- and Postoperative Assessment of Conotruncal Anomalies.Radiology. Cardiothoracic imaging · 2022Review
- Truncus arteriosus as presentation of PHACE syndrome.BMJ case reports · 2021Article
- Personalized Genetic Diagnosis of Congenital Heart Defects in Newborns.Journal of personalized medicine · 2021Review
- Contrast enhanced computed tomography findings of persistent truncus arteriosus; A rare congenital heart disease.Radiology case reports · 2020Article
- Persistent truncus arteriosus with absent semilunar valve in first trimester.Journal of medical ultrasonics (2001) · 2019Article
- Congenital heart diseases and cardiovascular abnormalities in 22q11.2 deletion syndrome: From well-established knowledge to new frontiers.American journal of medical genetics. Part A · 2018Review
- An infant with truncus arteriosus with situs inversus with single atrium: A case report.Journal of cardiology cases · 2017Article
- Persistent truncus arteriosus on dual source CT.Japanese journal of radiology · 2016Review
- 22q11.2 Deletion syndrome is associated with increased perioperative events and more complicated postoperative course in infants undergoing infant operative correction of truncus arteriosus communis or interrupted aortic arch.The Journal of thoracic and cardiovascular surgery · 2014Article
- New aspects of anesthetic management in congenital heart disease "common arterial trunk".Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Review
- 22q11.2 deletions in patients with conotruncal defects: data from 1,610 consecutive cases.Pediatric cardiology · 2013Article
- Truncus arteriosus: A major cause of proteinuria in children.Journal of cardiovascular disease research · 2011Article
- Prenatal diagnosis of truncus arteriosus using multiplanar display in 4D ultrasonography.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2010Article
- Role of perioperative transesophageal echocardiography in the management of adolescent truncus arteriosus: rare case report.Annals of cardiac anaesthesiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The association between truncus arteriosus and chromosome 22q11 deletion is well recognized, but the frequency of a chromosome 22q11 deletion has not been characterized in a large series of patients with truncus arteriosus, and little is known about cardiovascular morphologic features associated with a chromosome 22q11 deletion in this group of patients. We prospectively enrolled 50 consecutive patients with truncus arteriosus who were admitted to The Children's Hospital of Philadelphia between November 1991 and December 2001. Patients were studied for chromosome 22q11 deletion using fluorescence in situ hybridization. Correlations between anatomic features and chromosome 22q11 deletion were assessed. A chromosome 22q11 deletion was detected in 20 of the 50 patients (40%). Anatomic features that were significantly associated with a chromosome 22q11 deletion included a right-sided aortic arch, an abnormal aortic arch branching pattern, both abnormal sidedness and branching of the aortic arch, and the combined category of either abnormal sidedness or branching of the aortic arch. There was a trend toward the association of discontinuous pulmonary arteries with a chromosome 22q11 deletion. Interruption of the aortic arch and truncal valve morphology and function did not correlate significantly with the presence of a chromosome 22q11 deletion. In conclusion, a chromosome 22q11 deletion is common in patients with truncus arteriosus, and those with abnormal sidedness and/or branching of the aortic arch are significantly more likely to have a deletion. Clinically important anatomic variables, such as abnormalities of the truncal valve and interrupted aortic arch, were not associated with a chromosome 22q11 deletion in this series.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.