Trial reportEuropean journal of clinical nutrition2003
Effects of dietary intervention on IGF-I and IGF-binding proteins, and related alterations in sex steroid metabolism: the Diet and Androgens (DIANA) Randomised Trial.
Trial report in European journal of clinical nutrition, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04552405 (Preventive Anti-inflammatory Diet to Reduce Gastro-intestinal Inflammation in FAP Patients), which is not on this map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Preventive Anti-inflammatory Diet to Reduce Gastro-intestinal Inflammation in FAP Patients: a Prospective Pilot Study
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Vegetarian and vegan diets and cancer incidence: a systematic review and meta-analysis of prospective studies.European journal of epidemiology · 2026Pooled it
- Adherence to Mediterranean Diet and Risk of Pancreatic Cancer: Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2023Pooled it
- Sex hormone changes in a 24-mo dietary and physical activity randomized intervention trial in postmenopausal females: the Diet, physical Activity and Mammography study (DAMA) study.The American journal of clinical nutrition · 2025Trial
- Adherence to Dietary Recommendations after One Year of Intervention in Breast Cancer Women: The DIANA-5 Trial.Nutrients · 2021Trial
- A randomized controlled trial of diet and physical activity in BRCA mutation carriers.Familial cancer · 2014Trial
- Effects of dietary weight loss and exercise on insulin-like growth factor-I and insulin-like growth factor-binding protein-3 in postmenopausal women: a randomized controlled trial.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Trial
- Low-fat diet with omega-3 fatty acids increases plasma insulin-like growth factor concentration in healthy postmenopausal women.Nutrition research (New York, N.Y.) · 2013Trial
- Phase II prospective randomized trial of a low-fat diet with fish oil supplementation in men undergoing radical prostatectomy.Cancer prevention research (Philadelphia, Pa.) · 2011Trial
- The effects of a high-fruit and -vegetable, high-fiber, low-fat dietary intervention on serum concentrations of insulin, glucose, IGF-I and IGFBP-3.European journal of clinical nutrition · 2008Trial
- Oestrogen changes at menopause: insights into obesity-associated breast risk and outcomes.Nature reviews. Endocrinology · 2026Review
- Nuts about pemphigus? A cross-sectional investigation into the role of nuts intake in modulating disease severity.BMJ nutrition, prevention & health · 2026Article
- Weight-centric prevention of cancer.Obesity pillars · 2024Review
- Adherence to Diet Quality Indices and Breast Cancer Risk in the Italian ORDET Cohort.Nutrients · 2024Article
- Dietary patterns in relation to glioma: a case-control study.Cancer & metabolism · 2024Article
- Cardiovascular Disease and the Mediterranean Diet: Insights into Sex-Specific Responses.Nutrients · 2024Review
- Article
- How the COVID-19 pandemic has affected eating habits and physical activity in breast cancer survivors: the DianaWeb study.Journal of cancer survivorship : research and practice · 2023Article
- The Impact of Westernization on the Insulin/IGF-I Signaling Pathway and the Metabolic Syndrome: It Is Time for Change.International journal of molecular sciences · 2023Review
- Modern vision of the Mediterranean diet.Journal of preventive medicine and hygiene · 2022Review
- The influence of Mediterranean diet in acne pathogenesis and the correlation with insulin-like growth factor-1 serum levels: Implications and results.Dermatology reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the effects of a comprehensive change in dietary composition on endogenous hormone metabolism. The specific aim was to examine whether this intervention could lead to favourable changes in insulin sensitivity, levels of IGF-I and IGF-binding proteins (IGFBPs), and total and bioavailable testosterone and estradiol, that would be expected to reduce breast cancer risk.
designRandomised dietary intervention study; duration of 5 months. SUBJECTS: From a total of 99 postmenopausal women, who had elevated baseline plasma testosterone levels, 49 women were randomly assigned to the dietary intervention arm and the other 50 to a control group.
interventionsMain aspects of the dietary intervention were reductions in the intake of total fat and refined carbohydrates, an increase in the ratio of n-3 over n-6 plus saturated fatty acids, and increased intakes of foods rich in dietary fibre and phytooestrogens.
resultsRelative to the control group, women of the intervention group showed a significant reduction of body weight, waist circumference, fasting serum levels of testosterone, C peptide, glucose, and insulin area after glucose tolerance test, and a significant increase of serum levels of sex hormone-binding globulin, IGFBP-1, -2, and growth hormone-binding protein. Serum levels of IGF-I did not change.
conclusionThis comprehensive dietary intervention strategy proved to be successful in inducing changes in endogenous hormone metabolism that might eventually result in reduced breast cancer risk. Additional studies are needed to show whether the dietary intervention and related hormonal changes can be both maintained over longer periods, of at least several years.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.