ArticleNature neuroscience2003
Acute changes in short-term plasticity at synapses with elevated levels of neuronal calcium sensor-1.
Article in Nature neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
86 citing papers in PubMed.
- A computational theory of short-term synaptic plasticity: synapses learn to tell time.Research square · 2026Article
- Modulation of temporoammonic-CA1 synapses by neuropeptide Y is through Y1 receptors in mice.Neuropeptides · 2025Article
- Monoallelic de novoScience advances · 2024Article
- Visual cortex repetitive transcranial magnetic stimulation (rTMS) reversing neurodevelopmental impairments in adolescents with major psychiatric disorders (MPDs): A cross-species translational study.CNS neuroscience & therapeutics · 2024Article
- A novel α-conotoxin [D1G, ΔQ14] LvIC decreased mouse locomotor activity.Frontiers in pharmacology · 2024Article
- Distinct mechanism of TbPhysical chemistry chemical physics : PCCP · 2023Article
- Neuronal Calcium Sensor-1 Protects Cortical Neurons from Hyperexcitation and CaInternational journal of molecular sciences · 2022Article
- Bicuculline restores frequency-dependent hippocampal I/E ratio and circuit function in PGC-1ɑ null mice.Neuroscience research · 2022Article
- MicroRNAs and Synaptic Plasticity: From Their Molecular Roles to Response to Therapy.Molecular neurobiology · 2022Review
- Nanomolar affinity of EF-hands in neuronal calcium sensor 1 for bivalent cations Pb2+, Mn2+, and Hg2.Metallomics : integrated biometal science · 2022Article
- Use of Zebrafish Models to Boost Research in Rare Genetic Diseases.International journal of molecular sciences · 2021Review
- Neuronal Plasticity: Neuronal Organization is Associated with Neurological Disorders.Journal of molecular neuroscience : MN · 2020Review
- Neuronal Calcium Sensor 1 is up-regulated in response to stress to promote cell survival and motility in cancer cells.Molecular oncology · 2020Article
- NCS-1 expression is higher in basal breast cancers and regulates calcium influx and cytotoxic responses to doxorubicin.Molecular oncology · 2020Article
- Current Understanding of the Role of Neuronal Calcium Sensor 1 in Neurological Disorders.Molecular neurobiology · 2019Review
- TRPC channels regulate Ca2+-signaling and short-term plasticity of fast glutamatergic synapses.PLoS biology · 2019Article
- NCS-1 is a regulator of calcium signaling in health and disease.Biochimica et biophysica acta. Molecular cell research · 2018Review
- Target-cell-specific Short-term Plasticity Reduces the Excitatory Drive onto CA1 Interneurons Relative to Pyramidal Cells During Physiologically-derived Spike Trains.Neuroscience · 2018Article
- Transmitter release site organization can predict synaptic function at the neuromuscular junction.Journal of neurophysiology · 2018Article
- Functional Status of Neuronal Calcium Sensor-1 Is Modulated by Zinc Binding.Frontiers in molecular neuroscience · 2018Article
26 more citing papers are in PubMed but not listed here.
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4 authors.
Funding
Abstract
Short-term synaptic plasticity is a defining feature of neuronal activity, but the underlying molecular mechanisms are poorly understood. Depression of synaptic activity might be due to limited vesicle availability, whereas facilitation is thought to result from elevated calcium levels. However, it is unclear whether the strength and direction (facilitation versus depression) of plasticity at a given synapse result from preexisting synaptic strength or whether they are regulated by separate mechanisms. Here we show, in rat hippocampal cell cultures, that increases in the calcium binding protein neuronal calcium sensor-1 (NCS-1) can switch paired-pulse depression to facilitation without altering basal synaptic transmission or initial neurotransmitter release probability. Facilitation persisted during high-frequency trains of stimulation, indicating that NCS-1 can recruit 'dormant' vesicles. Our results suggest that NCS-1 acts as a calcium sensor for short-term plasticity by facilitating neurotransmitter output independent of initial release. We conclude that separate mechanisms are responsible for determining basal synaptic strength and short-term plasticity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.