ArticleBrain pathology (Zurich, Switzerland)2003
Direct comparison of demyelinating disease induced by the Daniel's strain and BeAn strain of Theiler's murine encephalomyelitis virus.
Article in Brain pathology (Zurich, Switzerland), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Pooled it
- High throughput method for detecting murine brain atrophy using a clinical 3T MRI.BMC medical imaging · 2023Article
- Article
- Contribution of Intravital Neuroimaging to Study Animal Models of Multiple Sclerosis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Theiler's virus-induced demyelinating disease as an infectious model of progressive multiple sclerosis.Frontiers in molecular neuroscience · 2022Review
- IFN-β Deficiency Results in Fatal or Demyelinating Disease in C57BL/6 Mice Infected With Theiler's Murine Encephalomyelitis Viruses.Frontiers in immunology · 2022Article
- Viral mouse models used to study multiple sclerosis: past and present.Archives of virology · 2021Review
- Connecting Neuroinflammation and Neurodegeneration in Multiple Sclerosis: Are Oligodendrocyte Precursor Cells a Nexus of Disease?Frontiers in cellular neuroscience · 2021Review
- Detection of Monocyte/Macrophage and Microglia Activation in the TMEV Model of Chronic Demyelination Using USPIO-Enhanced Ultrahigh-Field Imaging.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2020Article
- Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis.Journal of visualized experiments : JoVE · 2016Article
- Dynamic Changes of Microglia/Macrophage M1 and M2 Polarization in Theiler's Murine Encephalomyelitis.Brain pathology (Zurich, Switzerland) · 2015Article
- Virus infection, antiviral immunity, and autoimmunity.Immunological reviews · 2013Review
- Distinct spatio-temporal extracellular matrix accumulation within demyelinated spinal cord lesions in Theiler's murine encephalomyelitis.Brain pathology (Zurich, Switzerland) · 2012Article
- Lack of correlation of central nervous system inflammation and neuropathology with the development of seizures following acute virus infection.Journal of virology · 2011Article
- The relevance of animal models in multiple sclerosis research.Pathophysiology : the official journal of the International Society for Pathophysiology · 2011Article
- Neuropathogenesis of Theiler's murine encephalomyelitis virus infection, an animal model for multiple sclerosis.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010Review
- Machine learning approach identifies new pathways associated with demyelination in a viral model of multiple sclerosis.Journal of cellular and molecular medicine · 2010Article
- A mechanism of virus-induced demyelination.Interdisciplinary perspectives on infectious diseases · 2010Article
- Demyelinated axons and motor function are protected by genetic deletion of perforin in a mouse model of multiple sclerosis.Journal of neuropathology and experimental neurology · 2009Article
- Circulation of 3 lineages of a novel Saffold cardiovirus in humans.Emerging infectious diseases · 2008Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
We compared CNS disease following intracerebral injection of SJL mice with Daniel's (DA) and BeAn 8386 (BeAn) strains of Theiler's murine encephalomyelitis virus (TMEV). In tissue culture, DA was more virulent then BeAn. There was a higher incidence of demyelination in the spinal cords of SJL/J mice infected with DA as compared to BeAn. However, the extent of demyelination was similar between virus strains when comparing those mice that developed demyelination. Even though BeAn infection resulted in lower incidence of demyelination in the spinal cord, these mice showed significant brain disease similar to that observed with DA. There was approximately 100 times more virus specific RNA in the CNS of DA infected mice as compared to BeAn infected mice. This was reflected by more virus antigen positive cells (macrophages/microglia and oligodendrocytes) in the spinal cord white matter of DA infected mice as compared to BeAn. There was no difference in the brain infiltrating immune cells of DA or BeAn infected mice. However, BeAn infected mice showed higher titers of TMEV specific antibody. Functional deficits as measured by Rotarod were more severe in DA infected versus BeAn infected mice. These findings indicate that the diseases induced by DA or BeAn are distinct.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.