ArticleCancer gene therapy2003
A DNA vaccine expressing tyrosinase-related protein-2 induces T-cell-mediated protection against mouse glioblastoma.
Article in Cancer gene therapy, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Nucleic acid immunotherapeutics and vaccines: A promising approach to glioblastoma multiforme treatment.International journal of pharmaceutics · 2023Review
- Combination of DNA Vaccine and Immune Checkpoint Blockades Improves the Immune Response in an Orthotopic Unresectable Glioblastoma Model.Pharmaceutics · 2022Article
- Surface display of glycosylated Tyrosinase related protein-2 (TRP-2) tumour antigen on Lactococcus lactis.BMC biotechnology · 2015Article
- Glioma-associated antigen HEATR1 induces functional cytotoxic T lymphocytes in patients with glioma.Journal of immunology research · 2014Article
- Innovative DNA vaccine to break immune tolerance against tumor self-antigen.Human gene therapy · 2013Article
- Incomplete tumour control following DNA vaccination against rat gliomas expressing a model antigen.Acta neurochirurgica · 2013Article
- Downregulation of KIF23 suppresses glioma proliferation.Journal of neuro-oncology · 2012Article
- Article
- Antiglioma immunological memory in response to conditional cytotoxic/immune-stimulatory gene therapy: humoral and cellular immunity lead to tumor regression.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Article
- In vivo bioluminescence imaging in an experimental mouse model for dendritic cell based immunotherapy against malignant glioma.Journal of neuro-oncology · 2009Article
- DNA vaccines for cancer too.Cancer immunology, immunotherapy : CII · 2006Review
- 'Survival gene' Bcl-xl potentiates DNA-raised antitumor immunity.Gene therapy · 2005Article
- DNA vaccines against the human papillomavirus type 16 E6 or E7 oncoproteins.Cancer gene therapy · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A mouse glioblastoma cell line, termed GL261, was shown to express high levels of proteins involved in melanin biosynthesis such as the tyrosinase-related protein-2 (TRP-2), which is commonly overexpressed in melanoma cells. Mice injected with GL261 cells developed a CD8(+) T-cell response to TRP-2 and a DNA vaccine expressing human (h)TRP-2 induced CD8(+) T cells that recognized TRP-2 expressed by GL261 cells indicating that this melanoma-associated antigen may be suited for active immunotherapy of glioblastoma. Mice vaccinated with a DNA vaccine expressing TRP-2 were partially protected against subcutaneous, intravenous, or intracerebral challenge with the glioblastoma cells. Vaccine-induced protection against intracerebral challenge required both CD4(+) and CD8(+) T cells. Vaccine efficacy was enhanced upon addition of IL-12 as a genetic adjuvant. These results indicate that this well-defined melanoma-associated antigen can induce an adaptive immune response, which limits the intracerebral progression of a glioblastoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.