ArticleGenes and immunity2003
Age-related thymic involution in C57BL/6J x DBA/2J recombinant-inbred mice maps to mouse chromosomes 9 and 10.
Article in Genes and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 53 citations in OpenAlex.
- An integrative mechanistic model of thymocyte dynamics.Frontiers in immunology · 2024Article
- Article
- Revisiting the Pathoetiology of Multiple Sclerosis: Has the Tail Been Wagging the Mouse?Frontiers in immunology · 2020Review
- Thymic stromal cells: Roles in atrophy and age-associated dysfunction of the thymus.Experimental gerontology · 2018Review
- Intrinsic and Extrinsic Thymic Adrenergic Networks: Sex Steroid-Dependent Plasticity.Frontiers in endocrinology · 2018Review
- Thymic function in the regulation of T cells, and molecular mechanisms underlying the modulation of cytokines and stress signaling (Review).Molecular medicine reports · 2017Review
- Cooperative interaction of BMP signalling and Foxn1 gene dosage determines the size of the functionally active thymic epithelial compartment.Scientific reports · 2017Article
- Thymus: the next (re)generation.Immunological reviews · 2016Review
- Temporal fate mapping reveals age-linked heterogeneity in naive T lymphocytes in mice.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Age-specific variation in immune response in Drosophila melanogaster has a genetic basis.Genetics · 2012Article
- Thymus Size and Age-related Thymic Involution: Early Programming, Sexual Dimorphism, Progenitors and Stroma.Aging and disease · 2012Article
- Tbata modulates thymic stromal cell proliferation and thymus function.The Journal of experimental medicine · 2010Article
- Metabolic syndrome, hormones, and maintenance of T cells during aging.Current opinion in immunology · 2010Review
- Increased nicotinamide nucleotide transhydrogenase levels predispose to insulin hypersecretion in a mouse strain susceptible to diabetes.Diabetologia · 2007Article
- Article
- Genetic mapping of loci controlling diethylstilbestrol-induced thymic atrophy in the Brown Norway rat.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- Transforming growth factor-beta2 is involved in quantitative genetic variation in thymic involution.Blood · 2006Article
- Article
- The immune profile associated with acute allergic asthma accelerates clearance of influenza virus.Immunology and cell biologyArticle
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
Abstract
A comprehensive analysis of initial thymus size and involution rate has not been quantitated for different genetic backgrounds of mice, thus genetic linkage analysis of thymic involution has not been possible. Here, we have used a mathematical method to analyze the age-related decline in thymocyte count in C57BL/6 and DBA/2 mice and have observed that thymic involution could be best fit with a negative exponential curve N(t)=beta(0) x exp(-beta(1)t), where t represents the age (day). This regression model was applied to C57BL/6 x DBA/2 (B x D) recombinant inbred strains of mice to identify the genetic loci influencing age-related thymic involution. There was a dramatic genetic effect of B and D alleles on thymocyte count at young age and the age-related thymic involution rate. The strongest quantitative trait loci (QTL) influencing the rate of thymic involution were mapped to mouse chromosome (Chr) 9 (D9Mit20 at 62 cM) and Chr 10 (D10Mit61 at 32 cM). The strongest QTLs influencing the initial thymocyte count were mapped to ChrX (DXMit324 at 26.5 cM) and Chr 3 (D3Mit127 at 70.3 cM). The present study suggests that the initial thymus size and the rate of thymic involution may be influenced by a relatively small number of genetic loci.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.