ArticleJournal of clinical pathology2003
Diffuse and intestinal type gastric carcinomas differ in their expression of apoptosis related proteins.
Article in Journal of clinical pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
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- Decreased expression of TRIM3 gene predicts a poor prognosis in gastric cancer.Journal of gastrointestinal cancer · 2022Article
- Prognostic Significance of Tripartite Motif Containing 16 Expression in Patients with Gastric Cancer.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- The Ubiquitin Gene Expression Pattern and Sensitivity toInternational journal of molecular sciences · 2020Article
- Expression and Significance of MyD88 in Patients With Gastric Cardia Cancer in a High-Incidence Area of China.Frontiers in oncology · 2020Article
- THE CANONICAL WNT PATHWAY IN GASTRIC CARCINOMA.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2019Article
- Hereditary diffuse gastric cancer: One family's story.World journal of clinical cases · 2018Article
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- Expression analysis of matrix metalloproteinase-13 in human gastric cancer in the presence of Helicobacter Pylori infection.Cancer biomarkers : section A of Disease markers · 2017Article
- The expression of Bcl-2 and BID in gastric cancer cells.Journal of immunology research · 2014Article
- Hereditary diffuse gastric cancer: a family diagnosis and treatment.Clinical medicine & research · 2013Review
- The relationship of the active and latent forms of TGF-β1 with marrow fibrosis in essential thrombocythemia and primary myelofibrosis.Medical oncology (Northwood, London, England) · 2012Article
- Differential expression of MYC in H. pylori-related intestinal and diffuse gastric tumors.Virchows Archiv : an international journal of pathology · 2011Article
- Differential expression of apoptosis related proteins and nitric oxide synthases in Epstein Barr associated gastric carcinomas.World journal of gastroenterology · 2006Article
- Clinicopathological and immunohistochemical analysis of gastrointestinal stromal tumor.World journal of gastroenterology · 2006Article
- Differences in oxidative stress dependence between gastric adenocarcinoma subtypes.World journal of gastroenterology · 2006Article
- Differential expression of the eukaryotic release factor 3 (eRF3/GSPT1) according to gastric cancer histological types.Journal of clinical pathology · 2005Article
- Increased angiogenesis in primary myelofibrosis: latent transforming growth factor-β as a possible angiogenic factor.Revista brasileira de hematologia e hemoterapiaArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastric carcinomas can be divided into intestinal and diffuse types, with the last type having a worse prognosis.
aimsTo investigate whether specific patterns in the expression of apoptosis related proteins correlate with carcinoma type and/or prognosis
methodsThe expression of Fas, Bcl-2, Bax, Bcl-xl, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) was studied immunohistochemically and the extent of apoptosis and proliferation was investigated in 11 cases of intestinal type and in eight cases of diffuse type carcinoma.
resultsFas was expressed in all intestinal type and in one diffuse type carcinoma. Bcl-xl was expressed in 10 of 11 intestinal type and in one of eight diffuse type carcinomas. Bcl-2 was expressed in lamina propria immune cells. iNOS was expressed in six of 11 intestinal type and in four of eight diffuse type carcinomas, and COX-2 was expressed in eight of 11 intestinal type and in six of eight diffuse type carcinomas.
conclusionFas and Bcl-xl expression can differentiate between intestinal type and diffuse type gastric carcinomas. No differences in apoptosis and proliferation between intestinal type and diffuse type gastric carcinomas were observed.
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