ArticleMolecular and cellular biology2003
Inhibition of retinoblastoma protein degradation by interaction with the serpin plasminogen activator inhibitor 2 via a novel consensus motif.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 87 citations in OpenAlex.
- Regulation of macrophage fibrinolysis during venous thrombus resolution.Thrombosis research · 2024Article
- SerpinB2 deficiency is associated with delayed mammary tumor development and decreased pro-tumorigenic macrophage polarization.BMC cancer · 2024Article
- MacroH2A1.1 as a crossroad between epigenetics, inflammation and metabolism of mesenchymal stromal cells in myelodysplastic syndromes.Cell death & disease · 2023Article
- Deficiency of plasminogen activator inhibitor-2 results in accelerated tumor growth.Journal of thrombosis and haemostasis : JTH · 2020Article
- Plasminogen activator inhibitor 2 (PAI2) inhibits invasive potential of hepatocellular carcinoma cells in vitro via uPA- and RB/E2F1-related mechanisms.Hepatology international · 2019Article
- Down-regulation of SerpinB2 is associated with gefitinib resistance in non-small cell lung cancer and enhances invadopodia-like structure protrusions.Scientific reports · 2016Article
- SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma.Oncogene · 2016Article
- Tumor cell-expressed SerpinB2 is present on microparticles and inhibits metastasis.Cancer medicine · 2014Article
- TLR-induced PAI-2 expression suppresses IL-1β processing via increasing autophagy and NLRP3 degradation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Low expression of PAI-2 as a novel marker of portal vein tumor thrombosis and poor prognosis in hepatocellular carcinoma.World journal of surgery · 2013Article
- Regulation of apoptosis by Bcl-2 cysteine oxidation in human lung epithelial cells.Molecular biology of the cell · 2013Article
- The transcription factor C/EBP-β mediates constitutive and LPS-inducible transcription of murine SerpinB2.PloS one · 2013Article
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- Deciphering a global network of functionally associated post-translational modifications.Molecular systems biology · 2012Article
- Prostate cancer cell surface-associated keratin 8 and its implications for enhanced plasmin activity.The protein journal · 2012Article
- Malignant transformation in a defined genetic background: proteome changes displayed by 2D-PAGE.Molecular cancer · 2010Article
- SerpinB2 protection of retinoblastoma protein from calpain enhances tumor cell survival.Cancer research · 2008Article
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- The myxoid/round cell liposarcoma fusion oncogene FUS-DDIT3 and the normal DDIT3 induce a liposarcoma phenotype in transfected human fibrosarcoma cells.The American journal of pathology · 2006Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Plasminogen activator inhibitor-2 (PAI-2) is well documented as an inhibitor of the extracellular serine proteinase urokinase-type plasminogen activator (uPA) and is expressed in activated monocytes and macrophages, differentiating keratinocytes, and many tumors. Here we show that PAI-2 has a novel intracellular function as a retinoblastoma protein (Rb)-binding protein. PAI-2 colocalized with Rb in the nucleus and inhibited the turnover of Rb, which led to increases in Rb protein levels and Rb-mediated activities. Although PAI-2 contains an LXCXE motif, Rb binding was primarily mediated by the C-D interhelical region of PAI-2, which was found to bind to the C pocket of Rb. The C-D interhelical region of PAI-2 contained a novel Rb-binding motif, termed the PENF homology motif, which is shared by many cellular and viral Rb-binding proteins. PAI-2 expression also protected Rb from the accelerated degradation mediated by human papillomavirus (HPV) E7, leading to recovery of Rb and inhibition of E6/E7 mRNA expression. Protection of Rb by PAI-2 begins to explain many of the diverse, uPA-independent phenotypes conferred by PAI-2 expression. These results indicate that PAI-2 may enhance Rb's tumor suppressor activity and suggest a potential therapeutic role for PAI-2 against HPV-transformed lesions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.