ArticleMolecular and cellular biology2003
Rad52-independent accumulation of joint circular minichromosomes during S phase in Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Deficiency in homologous recombination is associated with changes in cell cycling and morphology in Saccharomyces cerevisiae.Experimental cell research · 2023Article
- Role for RNA:DNA hybrids in origin-independent replication priming in a eukaryotic system.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- TopBP1/Dpb11 binds DNA anaphase bridges to prevent genome instability.The Journal of cell biology · 2014Article
- Impaired manganese metabolism causes mitotic misregulation.The Journal of biological chemistry · 2012Article
- Evidence that a RecQ helicase slows senescence by resolving recombining telomeres.PLoS biology · 2007Article
- An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination.Molecular and cellular biology · 2006Article
- Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex.Molecular and cellular biology · 2006Article
- Impairment of replication fork progression mediates RNA polII transcription-associated recombination.The EMBO journal · 2005Article
- Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase.Genes & development · 2005Article
- Partial depletion of histone H4 increases homologous recombination-mediated genetic instability.Molecular and cellular biology · 2005Article
- Swi1 and Swi3 are components of a replication fork protection complex in fission yeast.Molecular and cellular biology · 2004Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the formation of X-shaped molecules consisting of joint circular minichromosomes (joint molecules) in Saccharomyces cerevisiae by two-dimensional neutral/neutral gel electrophoresis of psoralen-cross-linked DNA. The appearance of joint molecules was found to be replication dependent. The joint molecules had physical properties reminiscent of Holliday junctions or hemicatenanes, as monitored by strand displacement, branch migration, and nuclease digestion. Physical linkage of the joint molecules was detected along the entire length of the minichromosome and most likely involved newly replicated sister chromatids. Surprisingly, the formation of joint molecules was found to be independent of Rad52p as well as of other factors associated with a function in homologous recombination or in the resolution of stalled replication intermediates. These findings thus imply the existence of a nonrecombinational pathway(s) for the formation of joint molecules during the process of DNA replication or minichromosome segregation.
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