ArticleBiophysical journal2003
Investigating lipid composition effects on the mechanosensitive channel of large conductance (MscL) using molecular dynamics simulations.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Decisive structural elements in water and ion permeation through mechanosensitive channels of large conductance: insights from molecular dynamics simulation.RSC advances · 2022Article
- Synthetic cells in biomedical applications.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2022Review
- A Single Mutation in the Outer Lipid-Facing Helix of a Pentameric Ligand-Gated Ion Channel Affects Channel Function Through a Radially-Propagating Mechanism.Frontiers in molecular biosciences · 2021Article
- Influence of the Headgroup on the Interaction of Poly(ethylene oxide)-Poly(propylene oxide) Block Copolymers with Lipid Bilayers.The journal of physical chemistry. B · 2020Article
- When Stiffness Matters: Mechanosensing in Heart Development and Disease.Frontiers in cell and developmental biology · 2020Review
- Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation.Chemical reviews · 2019Review
- Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance.Chemical reviews · 2019Article
- Membrane Thickness as a Key Factor Contributing to the Activation of Osmosensors and Essential Ras Signaling Pathways.Frontiers in cell and developmental biology · 2018Review
- Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.Structure (London, England : 1993) · 2017Article
- Dihydrostreptomycin Directly Binds to, Modulates, and Passes through the MscL Channel Pore.PLoS biology · 2016Article
- Computational Investigation of the Effect of Lipid Membranes on Ion Permeation in Gramicidin A.Membranes · 2016Article
- The Combined Effect of Hydrophobic Mismatch and Bilayer Local Bending on the Regulation of Mechanosensitive Ion Channels.PloS one · 2016Article
- Breaking the hydrophobicity of the MscL pore: insights into a charge-induced gating mechanism.PloS one · 2015Article
- The mechanosensitive channel of small conductance (MscS) functions as a Jack-in-the box.Biochimica et biophysica acta · 2015Article
- Assembly and stability of Salmonella enterica ser. Typhi TolC protein in POPE and DMPE.Journal of biological physics · 2014Article
- Connection between oligomeric state and gating characteristics of mechanosensitive ion channels.PLoS computational biology · 2013Article
- Modeling and simulation of ion channels.Chemical reviews · 2012Review
- Controlled delivery of bioactive molecules into live cells using the bacterial mechanosensitive channel MscL.Nature communications · 2012Article
- Defining the role of the tension sensor in the mechanosensitive channel of small conductance.Biophysical journal · 2011Article
- An in vivo screen reveals protein-lipid interactions crucial for gating a mechanosensitive channel.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
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2 authors.
Funding
Abstract
Previous experimental work has shown that the functional properties of the mechanosensitive channel of large conductance (MscL) are affected by variations in lipid composition. Here, we utilize molecular dynamics simulations of Mycobacterium tuberculosis MscL to investigate such lipid composition effects on a molecular level. In particular, two sets of simulations were performed. In the first, trajectories using lipids with different headgroups (phosphatidylcholine and phosphatidylethanolamine) were compared. Protein-lipid interactions were clearly altered by the headgroup changes, leading to conformational differences in the C-terminal region of M. tuberculosis MscL. In the second set of simulations, lipid tails were gradually shortened, thinning the membrane over a molecular dynamics trajectory. These simulations showed evidence of hydrophobic matching between MscL and the lipid membrane, as previously proposed. For all simulations, protein-lipid interaction energies in the second transmembrane region were correlated to mutagenic data, emphasizing the importance of lipid interactions for proper MscL function.
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