ArticleBiophysical journal2003
Modeling the dependence of the period of intracellular Ca2+ waves on SERCA expression.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- Estradiol-Mediated Axogenesis of Hypothalamic Neurons Requires ERK1/2 and Ryanodine Receptors-Dependent Intracellular CaFrontiers in cellular neuroscience · 2019Article
- What Is Required for Neuronal Calcium Waves? A Numerical Parameter Study.Journal of mathematical neuroscience · 2018Article
- Multiscale Modeling Indicates That Temperature Dependent [Ca2+]i Spiking in Astrocytes Is Quantitatively Consistent with Modulated SERCA Activity.Neural plasticity · 2015Article
- Article
- Luminal Ca2+ depletion during the unfolded protein response in Xenopus oocytes: cause and consequence.Cell calcium · 2013Article
- Calcium signals driven by single channel noise.PLoS computational biology · 2010Article
- Ca2+ spiral waves in a spatially discrete and random medium.European biophysics journal : EBJ · 2009Article
- Spatiotemporal characteristics of calcium dynamics in astrocytes.Chaos (Woodbury, N.Y.) · 2009Article
- Mechanical and biochemical modeling of cortical oscillations in spreading cells.Biophysical journal · 2008Article
- A bidomain threshold model of propagating calcium waves.Journal of mathematical biology · 2008Article
- A buffering SERCA pump in models of calcium dynamics.Biophysical journal · 2006Article
- Dual sensitivity of sarcoplasmic/endoplasmic Ca2+-ATPase to cytosolic and endoplasmic reticulum Ca2+ as a mechanism of modulating cytosolic Ca2+ oscillations.The Biochemical journal · 2004Article
- Interplay between SERCA and sarcolemmal Ca2+ efflux pathways controls spontaneous release of Ca2+ from the sarcoplasmic reticulum in rat ventricular myocytes.The Journal of physiology · 2004Article
- Release currents of IP(3) receptor channel clusters and concentration profiles.Biophysical journal · 2004Article
- Ca2+-dependent redox modulation of SERCA 2b by ERp57.The Journal of cell biology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contrary to intuitive expectations, overexpression of sarco-endoplasmic reticulum (ER) Ca(2+) ATPases (SERCAs) in Xenopus oocytes leads to a decrease in the period and an increase in the amplitude of intracellular Ca(2+) waves. Here we examine these experimental findings by modeling Ca(2+) release using a modified Othmer-Tang-model. An increase in the period and a reduction in the amplitude of Ca(2+) wave activity are obtained when increases in SERCA density are simulated while keeping all other parameters of the model constant. However, Ca(2+) wave period can be reduced and the wave amplitude and velocity can be significantly increased when an increase in the luminal ER Ca(2+) concentration due to SERCA overexpression is incorporated into the model. Increased luminal Ca(2+) occurs because increased SERCA activity lowers cytosolic Ca(2+), which is partially replenished by Ca(2+) influx across the plasma membrane. These simulations are supported by experimental data demonstrating higher luminal Ca(2+) levels, decreased periods, increased amplitude, and increased velocity of Ca(2+) waves in response to increased SERCA density.
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