ArticleBiophysical journal2003
A model of calcium waves in pancreatic and parotid acinar cells.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 113 citations in OpenAlex.
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- Generalised Neuronal Calcium Dynamics of Membrane and ER in the Polar Dimension.Cell biochemistry and biophysics · 2024Article
- Analyzing fuzzy boundary value problems: a study on the influence of mitochondria and ER fluxes on calcium ions in neuron cells.Journal of bioenergetics and biomembranes · 2024Article
- CaPhysiological reviews · 2024Review
- Study of disorders in regulatory spatiotemporal neurodynamics of calcium and nitric oxide.Cognitive neurodynamics · 2023Article
- Effect of disturbances in neuronal calcium and IP3 dynamics on β-amyloid production and degradation.Cognitive neurodynamics · 2023Article
- To study the effect of ER flux with buffer on the neuronal calcium.European physical journal plus · 2023Article
- Simulation of Calcium Dynamics in Realistic Three-Dimensional Domains.Biomolecules · 2022Article
- Modeling calcium dynamics in neurons with endoplasmic reticulum: existence, uniqueness and an implicit-explicit finite element scheme.Communications in nonlinear science & numerical simulation · 2022Article
- Multiscale modeling of presynaptic dynamics from molecular to mesoscale.PLoS computational biology · 2022Article
- Article
- Calcium Dynamics and Water Transport in Salivary Acinar Cells.Bulletin of mathematical biology · 2021Review
- Quantifying the dose-dependent impact of intracellular amyloid beta in a mathematical model of calcium regulation in xenopus oocyte.PloS one · 2021Article
- CaThe Journal of physiology · 2019Article
- A Model ofBulletin of mathematical biology · 2019Article
- Applications of Spatio-temporal Mapping and Particle Analysis Techniques to Quantify Intracellular Ca2+ Signaling In Situ.Journal of visualized experiments : JoVE · 2019Article
- Spine-to-Dendrite Calcium Modeling Discloses Relevance for Precise Positioning of Ryanodine Receptor-Containing Spine Endoplasmic Reticulum.Scientific reports · 2018Article
- What Is Required for Neuronal Calcium Waves? A Numerical Parameter Study.Journal of mathematical neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
We construct a mathematical model of Ca(2+) wave propagation in pancreatic and parotid acinar cells. Ca(2+) release is via inositol trisphosphate receptors and ryanodine receptors that are distributed heterogeneously through the cell. The apical and basal regions are separated by a region containing the mitochondria. In response to a whole-cell, homogeneous application of inositol trisphosphate (IP(3)), the model predicts that 1), at lower concentrations of IP(3), the intracellular waves in pancreatic cells begin in the apical region and are actively propagated across the basal region by Ca(2+) release through ryanodine receptors; 2), at higher [IP(3)], the waves in pancreatic and parotid cells are not true waves but rather apparent waves, formed as the result of sequential activation of inositol trisphosphate receptors in the apical and basal regions; 3), the differences in wave propagation in pancreatic and parotid cells can be explained in part by differences in inositol trisphosphate receptor density; 4), in pancreatic cells, increased Ca(2+) uptake by the mitochondria is capable of restricting Ca(2+) responses to the apical region, but that this happens only for a relatively narrow range of [IP(3)]; and 5), at higher [IP(3)], the apical and basal regions of the cell act as coupled Ca(2+) oscillators, with the basal region partially entrained to the apical region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.