ArticleJournal of the Association for Research in Otolaryngology : JARO2003
Changes in cytochemistry of sensory and nonsensory cells in gentamicin-treated cochleas.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Expression of Calbindin-D28K in the Developing and Adult Mouse Cochlea.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2022Article
- Article
- Structural and Ultrastructural Changes to Type I Spiral Ganglion Neurons and Schwann Cells in the Deafened Guinea Pig Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2017Article
- Partial Aminoglycoside Lesions in Vestibular Epithelia Reveal Broad Sensory Dysfunction Associated with Modest Hair Cell Loss and Afferent Calyx Retraction.Frontiers in cellular neuroscience · 2017Article
- Expression of EFR3A in the mouse cochlea during degeneration of spiral ganglion following hair cell loss.PloS one · 2015Article
- Marker entry into vestibular perilymph via the stapes following applications to the round window niche of guinea pigs.Hearing research · 2012Article
- Comparative analysis of combination kanamycin-furosemide versus kanamycin alone in the mouse cochlea.Hearing research · 2011Article
- Localization of gentamicin uptake in the acutely isolated inner ear of the rat.International journal of physiology, pathophysiology and pharmacology · 2011Article
- [Endolymph homeostasis and Menière's disease: fundamentals, pathological changes, aminoglycosides].HNO · 2008Review
- 3p-- syndrome defines a hearing loss locus in 3p25.3.Hearing research · 2007Article
- Nuclear factor kappaB deficiency is associated with auditory nerve degeneration and increased noise-induced hearing loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Uptake of fluorescent gentamicin by vertebrate sensory cells in vivo.Hearing research · 2006Article
- Exogenous BDNF rescues rat spiral ganglion neurons in vivo.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2005Article
- Uptake of gentamicin by bullfrog saccular hair cells in vitro.Journal of the Association for Research in Otolaryngology : JARO · 2003Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Effects of a single local dose of gentamicin upon sensory and nonsensory cells throughout the cochlea were assessed by changes in immunostaining patterns for a broad array of functionally important proteins. Cytochemical changes in hair cells, spiral ganglion cells, and cells of the stria vascularis, spiral ligament, and spiral limbus were found beginning 4 days post administration. The extent of changes in immunostaining varied with survival time and with cell type and was not always commensurate with the degree to which individual cell types accumulated gentamicin. Outer hair cells, types I and II fibrocytes of the spiral ligament, and fibrocytes in the spiral limbus showed marked decreases in immunostaining for a number of constituents. In contrast, inner hair cells, type III fibrocytes and root cells of the spiral ligament, cells of the stria vascularis, and interdental cells in the spiral limbus showed less dramatic decreases, and in some cases they showed increases in immunostaining. Results indicate that, in addition to damaging sensory cells, local application of gentamicin results in widespread and disparate disruptions of a variety of cochlear cell types. Only in the case of ganglion cells was it apparent that the changes in nonsensory cells were secondary to loss or damage of hair cells. These results indicate that malfunction of the ear following gentamicin treatment is widespread and far more complex than simple loss of sensory elements. The results have implications for efforts directed toward detecting, preventing, and treating toxic effects of aminoglycosides upon the inner ear.
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