SynthesisHuman genetics2003
Molecular variation at the apolipoprotein B gene locus in relation to lipids and cardiovascular disease: a systematic meta-analysis.
Synthesis in Human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Association between the APOB XbaI and EcoRI polymorphisms and lipids in Chinese: a meta-analysis.Lipids in health and disease · 2015Pooled it
- Apolipoprotein B and angiotensin-converting enzyme polymorphisms and aerobic interval training: randomized controlled trial in coronary artery disease patients.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2018Trial
- Lipid metabolism, microglia, and stroke.Neural regeneration research · 2026Article
- Population Admixture andJournal of cardiovascular development and disease · 2026Article
- Review
- The interaction between apolipoprotein B insertion/deletion polymorphism and macronutrient intake on lipid profile and serum leptin and ghrelin levels in type 2 diabetes mellitus patients.European journal of nutrition · 2019Article
- Variants in the APOB gene was associated with Ischemic Stroke susceptibility in Chinese Han male population.Oncotarget · 2018Article
- Effect of SORT1, APOB and APOE polymorphisms on LDL-C and coronary heart disease in Pakistani subjects and their comparison with Northwick Park Heart Study II.Lipids in health and disease · 2016Article
- Parent-of-Origin Effects of the APOB Gene on Adiposity in Young Adults.PLoS genetics · 2015Article
- Insights from human congenital disorders of intestinal lipid metabolism.Journal of lipid research · 2015Review
- Helicobacter pylori vs coronary heart disease - searching for connections.World journal of cardiology · 2015Article
- The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults.Nutrition & metabolism · 2015Article
- Association between health-service use and multiplex genetic testing.Genetics in medicine : official journal of the American College of Medical Genetics · 2012Article
- Genetic variants involved in gallstone formation and capsaicin metabolism, and the risk of gallbladder cancer in Chilean women.World journal of gastroenterology · 2010Article
- Genomics of heart failure.Heart failure clinics · 2010Review
- New technologies for delineating and characterizing the lipid exome: prospects for understanding familial combined hyperlipidemia.Journal of lipid research · 2009Review
- Personalized medicine in coronary artery disease: insights from genomic research.Korean circulation journal · 2009Article
- Genetic determinants of serum lipid levels in Chinese subjects: a population-based study in Shanghai, China.European journal of epidemiology · 2009Article
- Multiple genetic determinants of plasma lipid levels in Caribbean Hispanics.Clinical biochemistry · 2008Article
- Genetic variation and atherosclerosis.Current genomics · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apolipoprotein B (apoB) is the sole protein component of low-density lipoprotein (LDL) and is thought to play an important role in atherogenesis. We performed a meta-analysis of the associations between the three most frequently investigated polymorphisms (XbaI, signal peptide insertion/deletion, EcoRI) in the apolipoprotein B (APOB) gene, lipid parameters, and the risk of ischemic heart disease (IHD). We restricted our analysis to Caucasians. Homozygotes for the XbaI X+ allele had significantly elevated levels of LDL cholesterol (LDL-C) and apoB, but a decreased risk (OR=0.80; 95%CI: 0.66-0.96) of IHD. Homozygosity for the signal peptide deletion allele was associated with similarly increased levels of LDL-C and apoB, and with an increased risk of IHD (OR=1.30; 95%CI: 1.08-1.58). Subjects homozygous for the rare EcoRI allele had significantly decreased levels of total and LDL cholesterol, but unaltered risk of IHD. We conclude that all three polymorphic apoB sites are associated with altered lipid levels, but not necessarily with a consistently altered risk of IHD. These data suggest that the relationship between apoB levels, hypercholesterolemia and IHD risk cannot have a simple molecular basis in the apoB gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.