ArticleImmunogenetics2003
Cloning and functional analyses of the mouse tapasin promoter.
Article in Immunogenetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Variants Within GenesFrontiers in genetics · 2022Article
- Sequence homology in eukaryotes (SHOE): interactive visual tool for promoter analysis.BMC genomics · 2018Article
- Identification of 14-3-3β gene as a novel miR-152 target using a proteome-based approach.The Journal of biological chemistry · 2014Article
- Impact of beta 2-microglobulin on tapasin expression and covalent association.Cellular immunology · 2012Article
- Human cytomegalovirus disrupts the major histocompatibility complex class I peptide-loading complex and inhibits tapasin gene transcription.Journal of virology · 2011Article
- Identification of E2F1 as an important transcription factor for the regulation of tapasin expression.The Journal of biological chemistry · 2010Article
- Distinct molecular mechanisms leading to deficient expression of ER-resident aminopeptidases in melanoma.Cancer immunology, immunotherapy : CII · 2010Article
- Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies.The Journal of biological chemistry · 2010Article
- What is the role of alternate splicing in antigen presentation by major histocompatibility complex class I molecules?Immunologic research · 2010Review
- Predicting combinatorial binding of transcription factors to regulatory elements in the human genome by association rule mining.BMC bioinformatics · 2007Article
- A distance difference matrix approach to identifying transcription factors that regulate differential gene expression.Genome biology · 2007Article
- Identification and regulatory analysis of rainbow trout tapasin and tapasin-related genes.Immunogenetics · 2006Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of tapasin is critical for an optimized MHC class I assembly and stable MHC class I surface expression. Thus, impaired MHC class I antigen expression of tumors can be attributable to tapasin downregulation. In order to understand the molecular mechanisms of deficient tapasin expression, the mouse tapasin promoter region and its 5'-flanking sequences were characterized. The mouse tapasin promoter lacks the TATA box and its transcription is initiated at multiple sites within a 51-nucleotide stretch. Sequence analyses revealed transcription factor binding motifs for NF-kappaB, GATA, E2F, p300, AP1, SP1 and IRF-1/2. Detailed analysis of deletion mutants and elimination of transcription factor binding motifs demonstrated an important role of NF-kappaB at position -468 for its basal activity, whereas E2F at position -229 represses constitutive promoter activity. Furthermore, the IRF-1/2 binding site is required for gamma interferon inducibility of the tapasin promoter in vitro, but also negatively interferes with its constitutive activity. Thus, characterization of the tapasin promoter represents the molecular basis for the understanding of the heterogeneous expression levels of tapasin under physiological and pathophysiological conditions.
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