ArticleJournal of clinical hypertension (Greenwich, Conn.)
The first hypertension trial comparing the effects of two fixed-dose combination therapy regimens on cardiovascular events: Avoiding Cardiovascular events through Combination therapy in Patients Living with Systolic Hypertension (ACCOMPLISH).
Article in Journal of clinical hypertension (Greenwich, Conn.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- The Polypill: A New Alternative in the Prevention and Treatment of Cardiovascular Disease.Journal of clinical medicine · 2024Review
- Article
- Hypertension and diabetes: should we treat early surrogates? What are the cons?Diabetes care · 2009Review
- Antihypertensive therapy, new-onset diabetes, and cardiovascular disease.International journal of clinical practice · 2009Review
- Combination therapy with an angiotensin-converting enzyme inhibitor and a calcium channel blocker.Journal of clinical hypertension (Greenwich, Conn.) · 2007Review
- Combination drug treatment of hypertension: have we come full circle?Current cardiology reports · 2004Review
- Combination therapy as first-line treatment for hypertension.Current hypertension reports · 2004Review
- The first hypertension trial comparing the effects of two fixed-dose combination therapy regimens on cardiovascular events: Avoiding Cardiovascular events through Combination therapy in Patients Living with Systolic Hypertension (ACCOMPLISH).Journal of clinical hypertension (Greenwich, Conn.)Article
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Authors and funding
2 authors.
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Abstract
Current recommendations for the treatment of hypertension clarify the need to achieve lower blood pressure levels in the general population (<140/90 mm Hg) and in specific high-risk patient groups such as patients with diabetes or chronic renal disease (<130/80 mm Hg). Further, it is evident that to reach appropriate blood pressure control, most patients with high blood pressure will require two or more antihypertensive agents. There is scarce clinical trial outcome evidence to guide clinicians in the selection of optimal combinations of antihypertensive classes for high-risk hypertensive patients. A new clinical trial, Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension (ACCOMPLISH), is the first large clinical trial to directly compare cardiovascular mortality and morbidity rates for two fixed-dose combination therapies. Results from ACCOMPLISH should provide much-needed guidance for selecting optimal combination therapy for high-risk hypertensive patients.
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