ArticleJournal of virology2003
Hepatitis C virus-like particle budding: role of the core protein and importance of its Asp111.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 60 citations in OpenAlex.
- Insights into the function of ESCRT and its role in enveloped virus infection.Frontiers in microbiology · 2023Review
- Activation of the CaViruses · 2022Article
- Review
- The Replacement of 10 Non-Conserved Residues in the Core Protein of JFH-1 Hepatitis C Virus Improves Its Assembly and Secretion.PloS one · 2015Article
- Incorporation of hepatitis C virus E1 and E2 glycoproteins: the keystones on a peculiar virion.Viruses · 2014Review
- Article
- Ultrastructural and quantitative analysis of the lipid droplet clustering induced by hepatitis C virus core protein.Cellular and molecular life sciences : CMLS · 2010Article
- Hepatitis C virus: assembly and release of virus particles.The Journal of biological chemistry · 2010Review
- Extending the knowledge in histochemistry and cell biology.Histochemistry and cell biology · 2010Review
- Characterization of hepatitis C virus core protein multimerization and membrane envelopment: revelation of a cascade of core-membrane interactions.Journal of virology · 2009Article
- Enhancement of the expression of HCV core gene does not enhance core-specific immune response in DNA immunization: advantages of the heterologous DNA prime, protein boost immunization regimen.Genetic vaccines and therapy · 2009Article
- Hepatitis C virus budding at lipid droplet-associated ER membrane visualized by 3D electron microscopy.Histochemistry and cell biology · 2008Article
- Viral detection by electron microscopy: past, present and future.Biology of the cell · 2008Article
- Article
- Molecular biology of hepatitis C virus.Journal of gastroenterology · 2007Review
- Hepatitis B virus subviral envelope particle morphogenesis and intracellular trafficking.Journal of virology · 2007Article
- Core protein domains involved in hepatitis C virus-like particle assembly and budding at the endoplasmic reticulum membrane.Cellular microbiology · 2007Article
- Core protein cleavage by signal peptide peptidase is required for hepatitis C virus-like particle assembly.The Journal of general virology · 2006Article
- Signal peptide cleavage and internal targeting signals direct the hepatitis C virus p7 protein to distinct intracellular membranes.Journal of virology · 2005Article
- Identification of residues in the hepatitis C virus core protein that are critical for capsid assembly in a cell-free system.Journal of virology · 2005Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the absence of a hepatitis C virus (HCV) culture system, the use of a Semliki Forest virus replicon expressing genes encoding HCV structural proteins that assemble into HCV-like particles provides an opportunity to study HCV morphogenesis. Using this system, we showed that the HCV core protein constitutes the budding apparatus of the virus and that its targeting to the endoplasmic reticulum by means of the signal sequence of E1 protein is essential for budding. In addition, the aspartic acid at position 111 in the HCV core protein sequence was found to be crucial for virus assembly, demonstrating the usefulness of this system for mapping amino acids critical to HCV morphogenesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.