ArticleJournal of virology2003
The cap region of topoisomerase I binds to sites near both ends of simian virus 40 T antigen.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- DNA damage-induced phosphorylation of a replicative DNA helicase results in inhibition of DNA replication through attenuation of helicase function.Nucleic acids research · 2024Article
- Modeling of the SV40 DNA Replication Machine.Genes · 2012Article
- Genotyping schemes for polyomavirus BK, using gene-specific phylogenetic trees and single nucleotide polymorphism analysis.Journal of virology · 2009Article
- Validation of BKV large T-antigen ATP-binding site as a target for drug discovery.Antiviral research · 2009Article
- Biologic diversity of polyomavirus BK genomic sequences: Implications for molecular diagnostic laboratories.Journal of medical virology · 2008Article
- Simian virus 40 DNA replication is dependent on an interaction between topoisomerase I and the C-terminal end of T antigen.Journal of virology · 2008Article
- Timed interactions between viral and cellular replication factors during the initiation of SV40 in vitro DNA replication.The Biochemical journal · 2007Article
- Cellular topoisomerase I modulates origin binding by bovine papillomavirus type 1 E1.Journal of virology · 2006Article
- Assembly of the replication initiation complex on SV40 origin DNA.Nucleic acids research · 2004Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Two independent binding sites on simian virus 40 (SV40) T antigen for topoisomerase I (topo I) were identified. One was mapped to the N-terminal domain (residues 83 to 160) by a combination of enzyme-linked immunosorbent assays (ELISAs) and glutathione S-transferase (GST) pull-down assays performed with various T antigen deletion mutants. The second was mapped to the C-terminal domain (residues 602 to 708). The region in human topo I that binds to both sites in T antigen was identified by ELISAs, GST pull-down assays, and double-hexamer binding assays with topo I deletion mutants. This region corresponds to a distinct domain on topo I known as the cap region that maps from residues 175 to 433. By combining these data with information about the structure of T-antigen double hexamers associated with origin DNA, we propose that the cap region of topo I associates specifically with both ends of the double hexamer bound to the SV40 origin to initiate DNA replication.
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