ArticleThe EMBO journal2003
The 3' ends of human pre-snRNAs are produced by RNA polymerase II CTD-dependent RNA processing.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 61 citations in OpenAlex.
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- Multiple Quality Control Checkpoints Safeguard Small Nuclear RNA Biogenesis and Prevent Assembly of Aberrant Spliceosomes.bioRxiv : the preprint server for biology · 2025Article
- Mutations in the non-coding RNU4ATAC gene affect the homeostasis and function of the Integrator complex.Nucleic acids research · 2023Article
- Oxidative stress induces Ser 2 dephosphorylation of the RNA polymerase II CTD and premature transcription termination.Transcription · 2021Article
- U2.3 Precursor Small Nuclear RNABio-protocol · 2021Article
- POINT technology illuminates the processing of polymerase-associated intact nascent transcripts.Molecular cell · 2021Article
- The RNA polymerase II subunit RPB-9 recruits the integrator complex to terminate Caenorhabditis elegans piRNA transcription.The EMBO journal · 2021Article
- Alternative splicing of DSP1 enhances snRNA accumulation by promoting transcription termination and recycle of the processing complex.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module.Nature communications · 2020Article
- DSP1 and DSP4 Act Synergistically in Small Nuclear RNA 3' End Maturation and Pollen Growth.Plant physiology · 2019Article
- snRNA 3' End Processing by a CPSF73-Containing Complex Essential for Development in Arabidopsis.PLoS biology · 2016Article
- Selective Degradation of Host RNA Polymerase II Transcripts by Influenza A Virus PA-X Host Shutoff Protein.PLoS pathogens · 2016Article
- The host Integrator complex acts in transcription-independent maturation of herpesvirus microRNA 3' ends.Genes & development · 2015Article
- The Integrator complex controls the termination of transcription at diverse classes of gene targets.Cell research · 2015Article
- The 5S rDNA high dynamism in Diplodus sargus is a transposon-mediated mechanism. Comparison with other multigene families and Sparidae species.Journal of molecular evolution · 2013Article
- A primate herpesvirus uses the integrator complex to generate viral microRNAs.Molecular cell · 2011Article
- The scaRNA2 is produced by an independent transcription unit and its processing is directed by the encoding region.Nucleic acids research · 2010Article
- HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response.The Journal of biological chemistry · 2009Article
- Transcription termination by nuclear RNA polymerases.Genes & development · 2009Article
- The assembly of a spliceosomal small nuclear ribonucleoprotein particle.Nucleic acids research · 2008Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proper 3' end formation of the human pre-snRNAs synthesized by pol II requires the cis-acting 3' box, although the precise function of this element has proved difficult to determine. In vivo, 3' end formation is tightly linked to transcription. However, we have now been able to obtain transcription-independent 3' box-dependent processing in vitro. This finally demonstrates that the 3' end of pre-snRNAs is produced by RNA processing rather than by termination of transcription. The phosphorylated form of the C-terminal domain (CTD) of pol II activates the processing event in vitro, consistent with our previous demonstration of the role of the CTD in pre-snRNA 3' end formation in vivo. In addition, we show that sequences upstream from the 3' box of the U2 snRNA gene influence 3' end formation both in vivo and in vitro.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.