ArticleThe EMBO journal2003
H2A.Z has a function reminiscent of an activator required for preferential binding to intergenic DNA.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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Who cites it
37 citing papers in PubMed, 69 citations in OpenAlex.
- Characterizing the regulatory effects of H2A.Z and SWR1-C on gene expression during hydroxyurea exposure in Saccharomyces cerevisiae.PLoS genetics · 2025Article
- What makes a histone variant a variant: Changing H2A to become H2A.Z.PLoS genetics · 2021Article
- Genome-wide identification of histone H2A and histone variant H2A.Z-interacting proteins by bPPI-seq.Cell research · 2017Article
- Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1.Nature structural & molecular biology · 2016Article
- Expression of Non-acetylatable H2A.Z in Myoblast Cells Blocks Myoblast Differentiation through Disruption of MyoD Expression.The Journal of biological chemistry · 2015Article
- Progress in epigenetic histone modification analysis by mass spectrometry for clinical investigations.Expert review of proteomics · 2015Review
- Expression and functionality of histone H2A variants in cancer.Oncotarget · 2014Review
- Article
- Mutations in non-acid patch residues disrupt H2A.Z's association with chromatin through multiple mechanisms.PloS one · 2013Article
- Single-molecule tools elucidate H2A.Z nucleosome composition.Journal of cell science · 2012Article
- Histone variant H2A.Z and RNA polymerase II transcription elongation.Molecular and cellular biology · 2011Article
- USP10 deubiquitylates the histone variant H2A.Z and both are required for androgen receptor-mediated gene activation.Nucleic acids research · 2011Article
- Histone H2A.Z acid patch residues required for deposition and function.Molecular genetics and genomics : MGG · 2011Article
- Expression of P. falciparum var genes involves exchange of the histone variant H2A.Z at the promoter.PLoS pathogens · 2011Article
- H2A.Z (Htz1) controls the cell-cycle-dependent establishment of transcriptional silencing at Saccharomyces cerevisiae telomeres.Genetics · 2011Article
- Article
- Loss of H2A.Z Is Not Sufficient to Determine Transcriptional Activity of Snf2-Related CBP Activator Protein or p400 Complexes.International journal of cell biology · 2011Article
- Regulation of DCC localization by HTZ-1/H2A.Z and DPY-30 does not correlate with H3K4 methylation levels.PloS one · 2011Article
- Decoding the epigenetic language of plant development.Molecular plant · 2010Review
- The role of histone modifications and variants in regulating gene expression in breast cancer.Journal of mammary gland biology and neoplasia · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
H2A.Z has been shown to regulate transcription in yeast, and that function resides in its C-terminal region as the reciprocal portion of H2A cannot substitute for the latter. We show that fusion of a transcriptional activating region to the C-terminal region of H2A, which is substituted for that of H2A.Z, can allow the chimera to fulfil the special role of H2A.Z in positive gene regulation, as well as complement growth deficiencies of htz1delta cells. We further show that the 'transcription' function of H2A.Z is linked to its ability to preferentially localize to certain intergenic DNA regions. Our results suggest that H2A.Z modulates functional interactions with transcription regulatory components, and thus increases its localization to promoters where it helps poise chromatin for gene activation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.