ArticleThe Journal of experimental medicine2003
Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization.
Article in The Journal of experimental medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 84 citations in OpenAlex.
- Opposite Genetic Effects of CMIP Polymorphisms on the Risk of Type 2 Diabetes and Obesity: A Family-Based Study in China.International journal of molecular sciences · 2018Trial
- CMIP as a novel candidate gene for neurodevelopmental and neuropsychiatric disorders.European journal of human genetics : EJHG · 2026Observational
- Downregulation of CMIP contributes to preeclampsia development by impairing trophoblast function via the PDE7B-cAMP pathway.Cellular and molecular life sciences : CMLS · 2025Article
- Understanding the Genetic Landscape of Gestational Diabetes: Insights into the Causes and Consequences of Elevated Glucose Levels in Pregnancy.Metabolites · 2024Review
- Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Pparγ-CD36 axis.Experimental & molecular medicine · 2023Article
- Identification of β2 microglobulin, the product of B2M gene, as a Host Factor for Vaccinia Virus Infection by Genome-Wide CRISPR genetic screens.PLoS pathogens · 2022Article
- Trends in pediatric nephrotic syndrome.World journal of nephrology · 2021Review
- The Enigmatic Emerging Role of the C-Maf Inducing Protein in Cancer.Diagnostics (Basel, Switzerland) · 2021Review
- Gangliosides in Podocyte Biology and Disease.International journal of molecular sciences · 2020Review
- CASK, the Soluble Glomerular Permeability Factor, Is Secreted by Macrophages in Patients With Recurrent Focal and Segmental Glomerulo-Sclerosis.Frontiers in immunology · 2020Article
- Minimal change nephrotic syndrome in patients infected with human immunodeficiency virus: a retrospective study of 8 cases.BMC nephrology · 2018Article
- CMIP is oncogenic in human gastric cancer cells.Molecular medicine reports · 2017Article
- Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.Nature genetics · 2017Article
- CMIP Promotes Proliferation and Metastasis in Human Glioma.BioMed research international · 2017Article
- Possible functional links among brain- and skull-related genes selected in modern humans.Frontiers in psychology · 2015Article
- A circulating antibody panel for pretransplant prediction of FSGS recurrence after kidney transplantation.Science translational medicine · 2014Article
- Immunopathogenesis of idiopathic nephrotic syndrome with relapse.Seminars in immunopathology · 2014Review
- Globularity and language-readiness: generating new predictions by expanding the set of genes of interest.Frontiers in psychology · 2014Article
- Nanobody-induced perturbation of LFA-1/L-plastin phosphorylation impairs MTOC docking, immune synapse formation and T cell activation.Cellular and molecular life sciences : CMLS · 2013Article
- Physiopathology of idiopathic nephrotic syndrome: lessons from glucocorticoids and epigenetic perspectives.Pediatric nephrology (Berlin, Germany) · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several arguments suggest that minimal change nephrotic syndrome (MCNS) results from yet unknown systemic disorder of T cell function. By screening a cDNA library from T cell relapse, we identified a new pleckstrin homology (PH) domain-containing protein encoded by a gene located on chromosome 16q24. Two alternative transcripts were identified. The first species (c-mip) was expressed in fetal liver, kidney, and peripheral blood mononuclear cells (PBMCs), but weakly detected in PBMCs from MCNS patients. The second form (Tc-mip, standing for truncated c-maf inducing protein), corresponds to subtracted transcript and lacks the NH2-terminal PH domain. The expression of Tc-mip was restricted to fetal liver, thymus, and MCNS PBMCs where it was specifically recruited in CD4+ T cells subset. Overexpression of Tc-mip in T cell Jurkat induced c-maf, transactivated the interleukin 4 gene and down-regulated the interferon gamma expression, characteristic of a Th2 commitment. Moreover, the overexpression of Tc-mip induced Src phosphorylation, T cell clustering, and a cellular redistribution of the cytoskeleton-associated L-plastin, by a PI3 kinase independent pathway. Tc-mip represents therefore the first identified protein, which links proximal signaling to c-maf induction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.