ArticleJournal of molecular medicine (Berlin, Germany)2003
The single nucleotide polymorphism -1131T>C in the apolipoprotein A5 (APOA5) gene is associated with elevated triglycerides in patients with hyperlipidemia.
Article in Journal of molecular medicine (Berlin, Germany), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Associations of the SLCO1B1 Polymorphisms With Hepatic Function, Baseline Lipid Levels, and Lipid-lowering Response to Simvastatin in Patients With Hyperlipidemia.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018Trial
- Plasma apolipoprotein A5 and triglycerides in type 2 diabetes.Diabetologia · 2006Trial
- An anti-ANGPTL3/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif.Journal of lipid research · 2022Article
- Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8.American journal of physiology. Endocrinology and metabolism · 2021Review
- Apolipoprotein A-V deficiency enhances chylomicron production in lymph fistula mice.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Cloning and characterization of a novel apolipoprotein gene, apolipoprotein AV, in tree shrews.Molecular biology reports · 2013Article
- Central obesity in males affected by a dyslipidemia-associated genetic polymorphism on APOA1/C3/A4/A5 gene cluster.Nutrition & diabetes · 2013Article
- -1131T>C and SW19 polymorphisms in APOA5 gene and lipid levels in type 2 diabetic patients.Molecular biology reports · 2012Article
- Association of the Apolipoprotein A5 Gene -1131T>C Polymorphism with Serum Lipids in Korean Subjects: Impact of Sasang Constitution.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Apolipoprotein A5-1131T>C polymorphism, but not APOE genotypes, increases susceptibility for dyslipidemia in children and adolescents.Molecular biology reports · 2011Article
- Interactions of the apolipoprotein A5 gene polymorphisms and alcohol consumption on serum lipid levels.PloS one · 2011Article
- Cerebrovascular atherosclerosis in type III hyperlipidemia is modulated by variation in the apolipoprotein A5 gene.European journal of medical research · 2011Article
- The apolipoprotein A5 -1131T>C promoter polymorphism in Koreans: association with plasma APOA5 and serum triglyceride concentrations, LDL particle size and coronary artery disease.Clinica chimica acta; international journal of clinical chemistry · 2009Article
- An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients.Journal of lipid research · 2008Article
- Apolipoprotein A5 gene C56G variant confers risk for the development of large-vessel associated ischemic stroke.Journal of neurology · 2008Article
- The -1131T>C polymorphism in the apolipoprotein A5 gene is related to hypertriglyceridemia in Taiwanese aborigines.The Kaohsiung journal of medical sciences · 2008Article
- Apoprotein A-V: an important regulator of triglyceride metabolism.Journal of inherited metabolic disease · 2008Review
- The D9N, N291S and S447X variants in the lipoprotein lipase (LPL) gene are not associated with Type III hyperlipidemia.BMC medical genetics · 2007Article
- Apolipoprotein A5 T-1131C variant confers risk for metabolic syndrome.Pathology oncology research : POR · 2007Article
- Give me A5 for lipoprotein hydrolysis!The Journal of clinical investigation · 2005Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The -1131T>C polymorphism in the newly identified apolipoprotein A5 (APOA5) gene has been associated with elevated plasma triglycerides. We determined its incidence in 915 patients attending a lipid outpatient clinic. The frequency of the C allele was significantly higher in patients with triglycerides above the 90th percentile and patients with type III hyperlipidemia compared to those with hypercholesterolemia. The C allele was associated with increased plasma triglycerides and decreased plasma HDL cholesterol, conditions associated with an increased risk of coronary heart disease. The effects on plasma lipids were only observed in overweight (BMI>25) patients and were greater in patients who were also carriers of a least one epsilon4 allele in the APOE gene. Thus additional genetic and/or metabolic factors are required in order for the triglyceride raising and HDL lowering effect of the -1131T>C polymorphism in APOA5 to be expressed.
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Registered trials
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