ArticleThe Journal of physiology2003
Role of villus microcirculation in intestinal absorption of glucose: coupling of epithelial with endothelial transport.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Three-Dimensional Morphogenesis in Canine Gut-on-a-Chip Using Intestinal Organoids Derived from Inflammatory Bowel Disease Patients.Journal of visualized experiments : JoVE · 2024Article
- Johannes Nathanael Lieberkühn (1711-1756): luminary eighteenth century anatomist and his illuminating discovery of intestinal glands.Anatomy & cell biology · 2023Review
- ADAMTS18Nature communications · 2022Article
- 3D in vitro morphogenesis of human intestinal epithelium in a gut-on-a-chip or a hybrid chip with a cell culture insert.Nature protocols · 2022Review
- Enzymatic hydrolysis and microbial fermentation: The most favorable biotechnological methods for the release of bioactive peptides.Food chemistry. Molecular sciences · 2021Article
- Biomaterials for Bioprinting Microvasculature.Chemical reviews · 2020Review
- Prenatal over- and undernutrition differentially program small intestinal growth, angiogenesis, absorptive capacity, and endocrine function in sheep.Physiological reports · 2020Article
- EGFR in enterocytes & endothelium and HIF1α in enterocytes are dispensable for massive small bowel resection induced angiogenesis.PloS one · 2020Article
- Lymphatic Vessel Network Structure and Physiology.Comprehensive Physiology · 2018Review
- Effects of a Lactobacillus salivarius mixture on performance, intestinal health and serum lipids of broiler chickens.PloS one · 2017Article
- A computer model simulating human glucose absorption and metabolism in health and metabolic disease states.F1000Research · 2016Article
- Micro/nanofabricated platforms for oral drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2015Review
- Transepithelial glucose transport and Na+/K+ homeostasis in enterocytes: an integrative model.American journal of physiology. Cell physiology · 2014Article
- The importance of villous physiology and morphology in mechanistic physiologically-based pharmacokinetic models.Pharmaceutical research · 2014Article
- Does apical membrane GLUT2 have a role in intestinal glucose uptake?F1000Research · 2014Review
- Endothelial surface layer degradation by chronic hyaluronidase infusion induces proteinuria in apolipoprotein E-deficient mice.PloS one · 2010Article
- Intestinal resection induces angiogenesis within adapting intestinal villi.Journal of pediatric surgery · 2009Article
- Development of an in vitro rat intestine segmental perfusion model to investigate permeability and predict oral fraction absorbed.Pharmaceutical research · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Capillaries in jejunal villi can absorb nutrients at rates several hundred times greater (per gram tissue) than capillaries in other tissues, including contracting skeletal muscle and brain. We here present an integrative hypothesis to account for these exceptionally large trans-endothelial fluxes and their relation to epithelial transport. Equations are developed for estimating concentration gradients of glucose across villus capillary walls, along paracellular channels and across subjunctional lateral membranes of absorptive cells. High concentrations of glucose discharged across lateral membranes to subjunctional intercellular spaces are delivered to abluminal surfaces of villus capillaries by convection-diffusion in intercellular channels without significant loss of concentration. Post-junctional paracellular transport thus provides the series link between epithelial and endothelial transport and makes possible the large trans-endothelial concentration gradients required for absorption to blood. Our analysis demonstrates that increases of villus capillary blood flow and permeability-surface area product (PS) are essential components of absorptive mechanisms: epithelial transport of normal digestive loads could not be sustained without concomitant increases in capillary blood flow and PS. The low rates of intestinal absorption found in anaesthetised animals may be attributed to inhibition of normal villus microvascular responses to epithelial transport.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.