ArticleAntimicrobial agents and chemotherapy2003
Molecular and biochemical characterization of OXA-45, an extended-spectrum class 2d' beta-lactamase in Pseudomonas aeruginosa.
Article in Antimicrobial agents and chemotherapy, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Activation of the ChvG-ChvI pathway promotes survival during cell wall stress inMolecular biology of the cell · 2025Article
- Antimicrobial Resistance in Romania: Updates on Gram-Negative ESCAPE Pathogens in the Clinical, Veterinary, and Aquatic Sectors.International journal of molecular sciences · 2023Review
- Whole Genome Sequence Analysis of Burkholderia contaminans FFH2055 Strain Reveals the Presence of Putative β-Lactamases.Current microbiology · 2019Article
- Extensively drug-resistant pseudomonas aeruginosa isolates containing blaVIM-2 and elements of Salmonella genomic island 2: a new genetic resistance determinant in Northeast Ohio.Antimicrobial agents and chemotherapy · 2014Article
- Acquired Class D β-Lactamases.Antibiotics (Basel, Switzerland) · 2014Review
- Class D β-lactamases: a reappraisal after five decades.Accounts of chemical research · 2013Review
- OXA-163, an OXA-48-related class D β-lactamase with extended activity toward expanded-spectrum cephalosporins.Antimicrobial agents and chemotherapy · 2011Article
- In vitro antimicrobial activity of ten medicinal plants against clinical isolates of oral cancer cases.Annals of clinical microbiology and antimicrobials · 2011Article
- Pseudomonas aeruginosa: resistance to the max.Frontiers in microbiology · 2011Article
- Extended-spectrum β-lactamases in Gram Negative Bacteria.Journal of global infectious diseases · 2010Article
- Diversity, epidemiology, and genetics of class D beta-lactamases.Antimicrobial agents and chemotherapy · 2010Review
- Molecular analysis of the sequences surrounding blaOXA-45 reveals acquisition of this gene by Pseudomonas aeruginosa via a novel ISCR element, ISCR5.Antimicrobial agents and chemotherapy · 2009Article
- Genetic structure associated with blaOXA-18, encoding a clavulanic acid-inhibited extended-spectrum oxacillinase.Antimicrobial agents and chemotherapy · 2008Article
- Carbapenemases: the versatile beta-lactamases.Clinical microbiology reviews · 2007Review
- Coproduction of novel 16S rRNA methylase RmtD and metallo-beta-lactamase SPM-1 in a panresistant Pseudomonas aeruginosa isolate from Brazil.Antimicrobial agents and chemotherapy · 2007Article
- blaVIM-2 and blaVIM-7 carbapenemase-producing Pseudomonas aeruginosa isolates detected in a tertiary care medical center in the United States: report from the MYSTIC program.Journal of clinical microbiology · 2007Article
- Prevalence of newer beta-lactamases in gram-negative clinical isolates collected in the United States from 2001 to 2002.Journal of clinical microbiology · 2006Article
- ISCR elements: novel gene-capturing systems of the 21st century?Microbiology and molecular biology reviews : MMBR · 2006Review
- Extended-spectrum beta-lactamases: a clinical update.Clinical microbiology reviews · 2005Review
- OXA-46, a new class D beta-lactamase of narrow substrate specificity encoded by a blaVIM-1-containing integron from a Pseudomonas aeruginosa clinical isolate.Antimicrobial agents and chemotherapy · 2005Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As part of the CANCER Antimicrobial Surveillance Program in North America, a clinical strain of Pseudomonas aeruginosa, strain 07-406, isolated in Texas was found to be resistant to all antimicrobials except polymyxin B. Genetic analysis of this isolate identified two unique extended-spectrum beta-lactamase genes. One, bla(VIM-7), encoded a metallo-beta-lactamase (unpublished data), and the other, bla(OXA-45), described here, encoded a class D extended-spectrum beta-lactamase. bla(OXA-45) was isolated on a Sau3A1 genomic fragment of 1.8 kb and encodes a protein of 264 amino acids with the highest identities to OXA-18 (65.9%), OXA-9 (42.8%), OXA-22 (40.2%), OXA-12 (38.6%), and OXA-29 (35.2%) but weak identities with other class D beta-lactamases. bla(OXA-45) was found to be harbored on a 24-kb plasmid in a region that displays high identities with a section of the 43-kb genomic island of Salmonella enterica serovar Typhimurium DT104. Biochemically OXA-45 is most similar to OXA-18 in its substrate profile and inhibition by clavulanic acid and is a member of the 2d' class of beta-lactamases.
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