ArticleAntimicrobial agents and chemotherapy2003
Molecular characterization of a new class 3 integron in Klebsiella pneumoniae.
Article in Antimicrobial agents and chemotherapy, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 120 citations in OpenAlex.
- Investigating the prevalence of class 1, 2, and 3 integrons in carbapenem-resistant Acinetobacter baumannii isolated from burn wound infections.Scientific reports · 2025Article
- Integron Functionality and Genome Innovation: An Update on the Subtle and Smart Strategy of Integrase and Gene Cassette Expression Regulation.Microorganisms · 2022Review
- Molecular Characterization of Class 1, 2 and 3 Integrons inInfection and drug resistance · 2021Article
- Molecular typing, and integron and associated gene cassette analyses inExperimental and therapeutic medicine · 2020Article
- Distribution of pathogenic bacteria in lower respiratory tract infection in lung cancer patients after chemotherapy and analysis of integron resistance genes in respiratory tract isolates of uninfected patients.Journal of thoracic disease · 2020Article
- Whole-genome sequencing resolves a polyclonal outbreak by extended-spectrum beta-lactam and carbapenem-resistantMicrobial genomics · 2019Article
- Resistance integrons; A Mini review.Caspian journal of internal medicine · 2019Review
- Prevalence of Integrons and Insertion Sequences in ESBL-ProducingInternational journal of environmental research and public health · 2018Article
- Impact of Wastewater Treatment on the Prevalence of Integrons and the Genetic Diversity of Integron Gene Cassettes.Applied and environmental microbiology · 2018Article
- Multidrug Resistance Mechanisms of Carbapenem Resistant Klebsiella pneumoniae Strains Isolated in Chongqing, China.Annals of laboratory medicine · 2017Article
- Gene Expression in Class 2 Integrons Is SOS-Independent and Involves Two Pc Promoters.Frontiers in microbiology · 2017Article
- Architecture of Class 1, 2, and 3 Integrons from Gram Negative Bacteria Recovered among Fruits and Vegetables.Frontiers in microbiology · 2016Article
- Resistance integrons: class 1, 2 and 3 integrons.Annals of clinical microbiology and antimicrobials · 2015Review
- Resistance gene pool to co-trimoxazole in non-susceptible Nocardia strains.Frontiers in microbiology · 2015Article
- Predominance of KPC-3 in a survey for carbapenemase-producing Enterobacteriaceae in Portugal.Antimicrobial agents and chemotherapy · 2015Article
- Integrons: past, present, and future.Microbiology and molecular biology reviews : MMBR · 2014Review
- Novel Class 1 Integrons in Multi-drug Resistant Isolates from Eastern China.Indian journal of microbiology · 2014Article
- Molecular characterization of clinical multidrug-resistant Klebsiella pneumoniae isolates.Annals of clinical microbiology and antimicrobials · 2014Article
- Analysis of the effect of integrons on drug-resistant Staphylococcus aureus by multiplex PCR detection.Molecular medicine reports · 2013Article
- Integron mediated multidrug resistance in extended spectrum beta-lactamase producing clinical isolates of Klebsiella pneumoniae.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2013Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Klebsiella pneumoniae FFUL 22K was isolated in April 1999 from the urine of an intensive care unit patient in Portugal. The strain showed an extended-spectrum cephalosporin resistance profile. A typical synergistic effect between cefotaxime or cefepime and clavulanic acid was observed. An Escherichia coli transformant displayed a similar resistance phenotype and harbored a ca. 9.4-kb plasmid (p22K9). Cloning experiments revealed that the extended-spectrum beta-lactamase was encoded by bla(GES-1), previously described in class 1 integrons from K. pneumoniae ORI-1 and Pseudomonas aeruginosa Pa695. Further sequence analysis demonstrated that the bla(GES-1) gene cassette was located on a new class 3 integron. The integron was 2863 bp long and consisted of an intI3 integrase gene, an attI3 recombination site, two promoter regions, and two gene cassettes. The IntI3 integrase was 98.8% identical to that of Serratia marcescens AK9373. The bla(GES-1) gene cassette was inserted at the attI3 site. The second gene cassette was the result of a fusion event between bla(OXA-10)-type and aac(6')-Ib gene cassettes and conferred resistance to kanamycin. This is the second class 3 integron reported and the first time that the bla(GES-1) gene cassette has been found on an integron belonging to this class, highlighting the considerable heterogeneity of their genetic environment and the spread of gene cassettes among different classes of integrons.
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