ArticleLipids2003
Antagonism of croton oil inflammation by topical emu oil in CD-1 mice.
Article in Lipids, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 79 citations in OpenAlex.
- Randomized phase II placebo-controlled study to evaluate the efficacy of topical pure emu oil for joint pain related to adjuvant aromatase inhibitor use in postmenopausal women with early breast cancer: JUST (Joints Under Study).Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Trial
- Topical treatment for acute phase Peyronie's disease utilizing a new gel, H-100: a randomized, prospective, placebo-controlled pilot study.International journal of impotence researchTrial
- The Effect of Ostrich Oil on Pain, Healing, and Recurrence of Chronic Anal Fissure: A Randomized Controlled Double-Blind Clinical Trial.Health science reports · 2026Article
- Article
- Seasonal and sexual variation in mRNA expression of selected adipokine genes affecting fat deposition and metabolism of the emu (Dromaius novaehollandiae).Scientific reports · 2022Article
- The Anti-Inflammatory Effect of a γ-Lactone Isolated from Ostrich Oil ofMolecules (Basel, Switzerland) · 2021Article
- Orally administered emu oil attenuates disease in a mouse model of Crohn's-like colitis.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- Development and characterization of ten novel microsatellite loci for the emu (Dromaius novaehollandiae) and genetic diversity of Japanese farm populations.Molecular biology reports · 2020Article
- The emu oil emulsified in egg lecithin and butylated hydroxytoluene enhanced the proliferation, stemness gene expression, and in vitro wound healing of adipose-derived stem cells.In vitro cellular & developmental biology. Animal · 2018Article
- Emu Oil Improves Clinical Indicators of Disease in a Mouse Model of Colitis-Associated Colorectal Cancer.Digestive diseases and sciences · 2018Article
- Emu oil offers protection in Crohn's disease model in rats.BMC complementary and alternative medicine · 2016Article
- Ratite oils promote keratinocyte cell growth and inhibit leukocyte activation.Poultry science · 2015Article
- Topical Anti-Inflammatory Activity of Oil from Tropidurus hispidus (Spix, 1825).Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Improvement of bioavailability and anti-inflammatory potential of curcumin in combination with emu oil.Inflammation · 2014Article
- Comparing the efficacy of Emu oil with clotrimazole and hydrocortisone in the treatment of seborrheic dermatitis: A clinical trial.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013Article
- Birds and people in semiarid northeastern Brazil: symbolic and medicinal relationships.Journal of ethnobiology and ethnomedicine · 2013Article
- Emu oil reduces small intestinal inflammation in the absence of clinical improvement in a rat model of indomethacin-induced enteropathy.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Emu oil increases colonic crypt depth in a rat model of ulcerative colitis.Digestive diseases and sciences · 2012Article
- Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid.The Journal of biological chemistry · 2009Article
- Non-invasive treatment in the management of Peyronie's disease.Therapeutic advances in urologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emu oil is derived from the emu (Dromaius novaehollandiae), which originated in Australia, and has been reported to have anti-inflammatory properties. Inflammation was induced in anesthetized CD-1 mice by applying 50 microL of 2% croton oil to the inner surface of the left ear. After 2 h, the area was treated with 5 microL of emu, fish, flaxseed, olive, or liquified chicken fat, or left untreated. Animals were euthanized at 6 h postapplication of different oils, and earplugs (EP) and plasma samples were collected. Inflammation was evaluated by change in earlobe thickness, increase in weight of EP tissue (compared to the untreated ear), and induction in cytokines interleukin (IL)-1alpha and tumor necrosis factor-alpha (TNF-alpha) in EP homogenates. Although reductions relative to control (croton oil) were noted for all treatments, auricular thickness and EP weights were significantly reduced (-72 and -71%, respectively) only in the emu oil-treated group. IL-1alpha levels in homogenates of auricular tissue were significantly reduced in the fish oil (-57%) and emu oil (-70%) groups relative to the control group. The cytokine TNF-alpha from auricular homogenates was significantly reduced in the olive oil (-52%) and emu oil (-60%) treatment groups relative to the control group. Plasma cytokine levels were not changed by croton oil treatment. Although auricular thickness and weight were significantly correlated with each other (r = 0.780, P < 0.003), auricular thickness but not weight was significantly correlated with cytokine IL-alpha (r = 0.750, P < 0.006) and TNF-alpha (r = 0.690, P < 0.02). These studies indicate that topical emu oil has anti-inflammatory properties in the CD-1 mouse that are associated with decreased auricular thickness and weight, and with the cytokines IL-1alpha and TNF-alpha.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.