ArticleOncogene2003
Bcl-2 mediates induction of neural differentiation.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Downregulated miR-18b-5p triggers apoptosis by inhibition of calcium signaling and neuronal cell differentiation in transgenic SOD1 (G93A) mice and SOD1 (G17S and G86S) ALS patients.Translational neurodegeneration · 2020Article
- TrkA regulates the regenerative capacity of bone marrow stromal stem cells in nerve grafts.Neural regeneration research · 2019Article
- The "neuro" of neuroblastoma: Neuroblastoma as a neurodevelopmental disorder.Annals of neurology · 2016Review
- Regulation of Bim in Health and Disease.Oncotarget · 2015Review
- Phospholipase D1 increases Bcl-2 expression during neuronal differentiation of rat neural stem cells.Molecular neurobiology · 2015Article
- X-linked inhibitor of apoptosis protein negatively regulates neuronal differentiation through interaction with cRAF and Trk.Scientific reports · 2013Article
- Odontoblast-targeted Bcl-2 overexpression impairs dentin formation.Journal of cellular biochemistry · 2010Article
- Molecular predictors of human nervous system cancer responsiveness to enediyne chemotherapy.Cancer chemotherapy and pharmacology · 2008Article
- Muller cell expression of glutamate cycle related proteins and anti-apoptotic proteins in early human retinal development.The British journal of ophthalmology · 2006Article
- Selective apoptosis of pluripotent mouse and human stem cells by novel ceramide analogues prevents teratoma formation and enriches for neural precursors in ES cell-derived neural transplants.The Journal of cell biology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bcl-2 is an antiapoptotic protein expressed in a wide variety of cell types. We have found that overexpression of bcl-2 in PC12 neural crest tumor cells leads to increased expression of neural differentiation-associated genes and decreased expression of proliferation-related genes. Culture growth rate decreases as well. Overexpression of bcl-2 also leads to increased expression of TrkA and increased phosphorylation of signal transductants in, albeit not specific for, the TrkA-MEK-ERK pathway. Blocking of NGF-mediated signaling through TrkA prevents Bcl-2-associated expression changes in differentiation-associated genes, raising the possibility that Bcl-2 mediates induction of neural differentiation through TrkA/NGF signaling.
Indexed as
Identifiers
12934111What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.