ArticleJournal of neurology, neurosurgery, and psychiatry2003
CSF galanin and cognition after shunt surgery in normal pressure hydrocephalus.
Article in Journal of neurology, neurosurgery, and psychiatry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- The effect of shunt surgery on neuropsychological performance in normal pressure hydrocephalus: a systematic review and meta-analysis.Journal of neurology · 2016Pooled it
- Post-surgical changes in brain metabolism detected by magnetic resonance spectroscopy in normal pressure hydrocephalus: results of a pilot study.Journal of neurology, neurosurgery, and psychiatry · 2007Trial
- Clinical Features of Idiopathic Normal Pressure Hydrocephalus: Critical Review of Objective Findings.Movement disorders clinical practice · 2023Review
- Cognitive Impairment in Idiopathic Normal Pressure Hydrocephalus.Neuroscience bulletin · 2022Review
- Motor skills, cognitive impairment, and quality of life in normal pressure hydrocephalus: early effects of shunt placement.Acta neurochirurgica · 2022Article
- There is more to NPH than lower body Parkinsonism.Acta neurochirurgica · 2021Article
- Galanin's implications for post-stroke improvement.Anatomy & cell biology · 2016Review
- A computerized neuropsychological test battery designed for idiopathic normal pressure hydrocephalus.Fluids and barriers of the CNS · 2014Article
- Improved learning and memory in aged mice deficient in amyloid beta-degrading neutral endopeptidase.PloS one · 2009Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background"Normal" pressure hydrocephalus (NPH) is associated with injury to neurotransmitter and neuropeptide systems that recovers after surgery. This could be linked to changes in galanin, a neuropeptide with inhibitory effects on basal forebrain cognitive function.
objectiveTo examine changes in CSF galanin concentrations in patients with normal pressure hydrocephalus undergoing shunt surgery, and to investigate the relation between these changes and cognitive functioning.
methodsEight patients underwent surgery for idiopathic normal pressure hydrocephalus. Lumbar CSF galanin determinations, cognitive status, and clinical status were quantified before operation and six months after. Cognition was assessed by an extensive battery of tests measuring attention, memory, speed of mental processing, visuospatial function, and frontal lobe function.
resultsCSF galanin concentration decreased after surgery. This reduction correlated with improved clinical and cognitive functioning, specifically with attention and visuomotor speed, visuoconstructive and frontal functioning, and clinical status according to the NPH scale, including the sphincter and cognitive components.
conclusionsThe cognitive and clinical improvement after shunt implantation correlated with CSF galanin levels, suggesting that the distribution or function of this agent involves cerebral structures that have some potential for recovery. In this study, galanin was related to several cognitive functions that may be associated with the fronto-subcortical deficits underlying cognitive dysfunction in normal pressure hydrocephalus.
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