ArticleInfection and immunity2003
Differential role of MyD88 in macrophage-mediated responses to opportunistic fungal pathogens.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 126 citations in OpenAlex.
- MyD88-mediated chimaeric antigen receptor macrophages suppress brain metastasis using target-specific phagocytosis.Nature biomedical engineering · 2026Article
- Disruption of Myd88 in a salmonid epithelioid cell line reveals its contribution to bacterial detection and immune response.Cell and tissue research · 2025Article
- ControllingInfection and immunity · 2024Review
- IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation.The Journal of experimental medicine · 2023Article
- A clash on the Toll pathway: competitive action between pesticides and zymosan A on components of innate immunity inFrontiers in immunology · 2023Article
- Role of toll-like receptors and nod-like receptors in acute lung infection.Frontiers in immunology · 2023Review
- TLR Agonists as Mediators of Trained Immunity: Mechanistic Insight and Immunotherapeutic Potential to Combat Infection.Frontiers in immunology · 2020Review
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- Article
- Interleukin 1α Is Critical for Resistance against Highly Virulent Aspergillus fumigatus Isolates.Infection and immunity · 2017Article
- PU.1 serves a critical role in the innate defense against Aspergillus fumigatus via dendritic cell-associated C-type lectin receptor-1 and toll-like receptors-2 and 4 in THP-1-derived macrophages.Molecular medicine reports · 2017Article
- Inhibition of CBLB protects from lethal Candida albicans sepsis.Nature medicine · 2016Article
- MyD88-dependent signaling drives host survival and early cytokine production during Histoplasma capsulatum infection.Infection and immunity · 2015Article
- Innate Defense against Fungal Pathogens.Cold Spring Harbor perspectives in medicine · 2014Review
- New insights into innate immune control of systemic candidiasis.Medical mycology · 2014Review
- Cell surface changes in the Candida albicans mitochondrial mutant goa1Δ are associated with reduced recognition by innate immune cells.Cellular microbiology · 2013Article
- Presentation of phagocytosed antigens by MHC class I and II.Traffic (Copenhagen, Denmark) · 2013Review
- Innate antifungal immunity: the key role of phagocytes.Annual review of immunology · 2011Review
- Innate immunity to Aspergillus species.Clinical microbiology reviews · 2009Review
- Macrophage-mediated responses to Candida albicans in mice expressing the human immunodeficiency virus type 1 transgene.Infection and immunity · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Toll-like receptors mediate macrophage recognition of microbial ligands, inducing expression of microbicidal molecules and cytokines via the adapter protein MyD88. We investigated the role of MyD88 in regulating murine macrophage responses to a pathogenic yeast (Candida albicans) and mold (Aspergillus fumigatus). Macrophages derived from bone marrow of MyD88-deficient mice (MyD88(-/-)) demonstrated impaired phagocytosis and intracellular killing of C. albicans compared to wild-type (MyD88(+/+)) macrophages. In contrast, ingestion and killing of A. fumigatus conidia was MyD88 independent. Cytokine production by MyD88(-/-) macrophages in response to C. albicans yeasts and hyphae was substantially decreased, but responses to A. fumigatus hyphae were preserved. These results provide evidence that MyD88 signaling is involved in phagocytosis and killing of live C. albicans, but not A. fumigatus. The differential role of MyD88 may represent one mechanism by which macrophages regulate innate responses specific to different pathogenic fungi.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.