ArticleInfection and immunity2003
The Hag protein of Moraxella catarrhalis strain O35E is associated with adherence to human lung and middle ear cells.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- A global perspective on the genomics ofMicrobial genomics · 2025Article
- Correlation ofEmerging microbes & infections · 2022Article
- Optical Identification of Middle Ear Infection.Molecules (Basel, Switzerland) · 2020Review
- Persistence of Moraxella catarrhalis in Chronic Obstructive Pulmonary Disease and Regulation of the Hag/MID Adhesin.The Journal of infectious diseases · 2019Article
- Mutations in bacterial genes induce unanticipated changes in the relationship between bacterial pathogens in experimental otitis media.Royal Society open science · 2018Article
- Bacterial infections in patients with primary ciliary dyskinesia: Comparison with cystic fibrosis.Chronic respiratory disease · 2017Review
- A Moraxella catarrhalis two-component signal transduction system necessary for growth in liquid media affects production of two lysozyme inhibitors.Infection and immunity · 2015Article
- Identification of an outer membrane lipoprotein involved in nasopharyngeal colonization by Moraxella catarrhalis in an animal model.Infection and immunity · 2014Article
- Moraxella catarrhalis expresses a cardiolipin synthase that impacts adherence to human epithelial cells.Journal of bacteriology · 2014Article
- Moraxella catarrhalis uses a twin-arginine translocation system to secrete the β-lactamase BRO-2.BMC microbiology · 2013Article
- Article
- Prasinoviruses of the marine green alga Ostreococcus tauri are mainly species specific.Journal of virology · 2012Article
- Physiologic cold shock of Moraxella catarrhalis affects the expression of genes involved in the iron acquisition, serum resistance and immune evasion.BMC microbiology · 2011Article
- The Moraxella catarrhalis nitric oxide reductase is essential for nitric oxide detoxification.Journal of bacteriology · 2011Article
- Hag mediates adherence of Moraxella catarrhalis to ciliated human airway cells.Infection and immunity · 2009Article
- Identification of a bacteriocin and its cognate immunity factor expressed by Moraxella catarrhalis.BMC microbiology · 2009Article
- Molecular aspects of Moraxella catarrhalis pathogenesis.Microbiology and molecular biology reviews : MMBR · 2009Review
- Identification of domains of the Hag/MID surface protein recognized by systemic and mucosal antibodies in adults with chronic obstructive pulmonary disease following clearance of Moraxella catarrhalis.Clinical and vaccine immunology : CVI · 2009Article
- Identification of a repressor of a truncated denitrification pathway in Moraxella catarrhalis.Journal of bacteriology · 2008Article
- Modular arrangement of allelic variants explains the divergence in Moraxella catarrhalis UspA protein function.Infection and immunity · 2008Article
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4 authors.
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Abstract
Previous studies have demonstrated that the Moraxella catarrhalis surface antigen UspA1 is an adhesin for Chang human conjunctival cells. The present report demonstrates that lack of UspA1 expression does not affect the adherence of strain O35E to A549 human lung cells or primary cultures of human middle ear epithelial (HMEE) cells. These results imply that another molecule mediates the adherence of M. catarrhalis to these two cell lines. To identify this adhesin, strain O35E was mutagenized with a transposon and 1,000 mutants were screened in a microcolony formation assay using A549 cells. Nine independent isolates exhibited an 8- to 19-fold reduction in adherence and contained a transposon in the same locus. Nucleotide sequence data and PCR analysis indicated that the transposons were inserted in different locations in the gene encoding the surface protein Hag. Quantitative assays using one representative transposon mutant, O35E.TN2, showed considerably decreased binding to A549 as well as HMEE cells. However, this mutant adhered at wild-type levels to Chang conjunctival cells. These findings suggest that the M. catarrhalis Hag protein is an adhesin for cell lines derived from human lung and middle ear tissues.
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