ArticleInfection and immunity2003
Mice lacking inducible nitric oxide synthase demonstrate impaired killing of Porphyromonas gingivalis.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- Skeletal Muscle, Skin, and Bone as Three Major Nitrate Reservoirs in Mammals: Chemiluminescence andNutrients · 2024Article
- Article
- AT1 and AT2 Receptor Knockout Changed Osteonectin and Bone Density in Mice in Periodontal Inflammation Experimental Model.International journal of molecular sciences · 2021Article
- In Vivo Antibacterial Efficacy of Nitric Oxide-Releasing Hyperbranched Polymers againstMolecular pharmaceutics · 2019Article
- The expression of a nitric oxide derivative, tissue inhibitors of metalloproteinase-3, and tissue inhibitors of metalloproteinase-4 in chronic periodontitis with type 2 diabetes mellitus.Journal of periodontal & implant science · 2013Article
- Hyperlipidemia impaired innate immune response to periodontal pathogen porphyromonas gingivalis in apolipoprotein E knockout mice.PloS one · 2013Article
- Porphyromonas gingivalis-host interactions in a Drosophila melanogaster model.Infection and immunity · 2011Article
- Porphyromonas gingivalis virulence in a Drosophila melanogaster model.Infection and immunity · 2011Article
- Immune response of macrophages from young and aged mice to the oral pathogenic bacterium Porphyromonas gingivalis.Immunity & ageing : I & A · 2010Article
- Microbial hijacking of complement-toll-like receptor crosstalk.Science signaling · 2010Article
- Signaling mechanisms involved in altered function of macrophages from diet-induced obese mice affect immune responses.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Porphyromonas gingivalis, gamma interferon, and a proapoptotic fibronectin matrix form a synergistic trio that induces c-Jun N-terminal kinase 1-mediated nitric oxide generation and cell death.Infection and immunity · 2008Article
- Importance of TLR2 in early innate immune response to acute pulmonary infection with Porphyromonas gingivalis in mice.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Proinflammatory and antimicrobial nitric oxide in gingival fluid of diabetic patients with periodontal disease.Infection and immunity · 2006Article
- Review
- Roles of the host oxidative immune response and bacterial antioxidant rubrerythrin during Porphyromonas gingivalis infection.PLoS pathogens · 2006Article
- Protease-activated receptor-2 activation: a major role in the pathogenesis of Porphyromonas gingivalis infection.The American journal of pathology · 2006Article
- HIF-1alpha expression regulates the bactericidal capacity of phagocytes.The Journal of clinical investigation · 2005Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Porphyromonas gingivalis is a primary etiological agent of generalized severe periodontitis, and emerging data suggest the importance of reactive oxygen and nitrogen species in periodontal tissue damage, as well as in microbial killing. Since nitric oxide (NO) released from inducible NO synthase (iNOS) has been shown to possess immunomodulatory, cytotoxic, and antibacterial effects in experimental models, we challenged iNOS-deficient (iNOS(-/-)) mice with P. gingivalis by using a subcutaneous chamber model to study the specific contribution of NO to host defense during P. gingivalis infection. iNOS(-/-) mice inoculated with P. gingivalis developed skin lesions and chamber rejection with higher frequency and to a greater degree than similarly challenged C57BL/6 wild-type (WT) mice. Chamber fluid from iNOS(-/-) mice possessed significantly more P. gingivalis than that of WT mice. The immunoglobulin G responses to P. gingivalis in serum was similar in WT and iNOS(-/-) mice, and the inductions of tumor necrosis factor alpha, interleukin-1 beta and interleukin-6, and prostaglandin E(2) were comparable between the two mouse strains. Although no differences in total leukocyte counts in chamber fluids were observed between iNOS(-/-) and WT mice, the percentage of dead polymorphonuclear leukocytes (PMNs) was significantly greater in iNOS(-/-) mouse chamber fluids than that of WT samples. Interestingly, casein-elicited PMNs from iNOS(-/-) mice released more superoxide than did WT PMNs when stimulated with P. gingivalis. These results indicate that modulation of superoxide levels is a mechanism by which NO influences PMN function and that NO is an important element of the host defense against P. gingivalis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.