ArticleNucleic acids research2003
Fission yeast Rhp51 is required for the maintenance of telomere structure in the absence of the Ku heterodimer.
Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A CRISPR/Cas9-induced blunt-end telomere system in S. pombe reveals RNase H2-dependent RNA primer removal at the terminal Okazaki fragment of lagging telomeres.Nucleic acids research · 2026Article
- Eroded telomeres are rearranged in quiescent fission yeast cells through duplications of subtelomeric sequences.Nature communications · 2017Article
- Acentric chromosome ends are prone to fusion with functional chromosome ends through a homology-directed rearrangement.Nucleic acids research · 2016Article
- Ku stabilizes replication forks in the absence of Brc1.PloS one · 2015Article
- Article
- Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1.The Journal of cell biology · 2012Article
- Roles of heterochromatin and telomere proteins in regulation of fission yeast telomere recombination and telomerase recruitment.The Journal of biological chemistry · 2010Article
- Recombination-based telomere maintenance is dependent on Tel1-MRN and Rap1 and inhibited by telomerase, Taz1, and Ku in fission yeast.Molecular and cellular biology · 2008Article
- Microhomology-mediated end joining in fission yeast is repressed by pku70 and relies on genes involved in homologous recombination.Genetics · 2007Article
- Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere loss.Molecular biology of the cell · 2007Article
- Fission yeast Dna2 is required for generation of the telomeric single-strand overhang.Molecular and cellular biology · 2004Article
- A novel allele of fission yeast rad11 that causes defects in DNA repair and telomere length regulation.Nucleic acids research · 2003Article
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8 authors.
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Abstract
The Schizosaccharomyces pombe Ku70-Ku80 heterodimer is required for telomere length regulation. Lack of pku70+ results in telomere shortening and striking rearrangements of telomere-associated sequences. We found that the rearrangements of telomere-associated sequences in pku80+ mutants are Rhp51 dependent, but not Rad50 dependent. Rhp51 bound to telomere ends when the Ku heterodimer was not present at telomere ends. We also found that the single-stranded G-rich tails increased in S phase in wild-type strains, while deletion of pku70+ increased the single-stranded overhang in both G2 and S phase. Based on these observations, we propose that Rhp51 binds to the G-rich overhang and promotes homologous pairing between two different telomere ends in the absence of Ku heterodimer. Moreover, pku80 rhp51 double mutants showed a significantly reduced telomere hybridization signal. Our results suggest that, although Ku heterodimer sequesters Rhp51 from telomere ends to inhibit homologous recombination activity, Rhp51 plays important roles for the maintenance of telomere ends in the absence of the Ku heterodimer.
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